通过与（3-氧代吲哚啉-2-亚基）脲一步反应实现多壁碳纳米管-羧基的功能化及其对胃癌的体外抗肿瘤研究
Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer.
作者信息
Heidari-Keshel Saeed, Entezari Mahdieh, Rezaei-Tavirani Mostafa, Ebrahimi Maryam, Rezaei-Tavirani Majid
机构信息
Proteomics Research Center, Faculty of Paramedical sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran.
Department of Chemistry, Islamic Azad University, Shahre-Qods Branch, Shahre-Qods, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2013;6(Suppl 1):S39-44.
AIM
In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate.
BACKGROUND
Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study.
PATIENTS AND METHODS
MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed.
RESULTS
The two bands at around 2800-2900 cm(-1) which are seen in functionalized product are attributed to the CH stretching of MWNT-COOH defects.
CONCLUSION
Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.
目的
在本研究中，我们尝试以一种新的功能化方法制备一种纳米化合物作为抗胃癌候选物。
背景
纳米管的功能化是改变其生物学特性的一种有用途径。（3-氧代吲哚-2-亚基）脲是一种由异吲哚酮和尿素组成的化合物，可用于癌症研究。
患者与方法
MWNT-COOH通过该化合物进行一步反应功能化，这是改性中的一个新类别。产物已通过傅里叶变换红外光谱（FT-IR）、拉曼光谱和扫描电子显微镜（SEM）进行研究。还用人类胃癌细胞进行了抗癌研究，并通过MTT法检测活细胞数量。
结果
在功能化产物中出现的位于2800 - 2900 cm⁻¹ 附近的两个谱带归因于MWNT-COOH缺陷处的CH伸缩振动。
结论
细胞实验结果表明，与其他样品相比，功能化纳米管对癌细胞的毒性更大，可作为化疗的候选材料。
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