Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical sciences, Tehran, Iran.
Arch Iran Med. 2009 Nov;12(6):576-83.
Although the global incidence of gastric cancer has been decreased dramatically in recent decades, it is the most common cancer in north and northwest Iran. The wide variation in incidence across different geographical areas and higher proportion of cardia cancer are two main characteristics of gastric cancer in Iran. Current investigations indicate that a high prevalence of H.pylori infection, high dietary intake of salt and smoking are the main environmental factors of gastric cancer in Iran. Gastroesophageal reflux disease is another contributing factor in populations with a higher incidence of gastric cardia cancer. While interventions on modifiable environmental risk factors should be considered as the main modality to reduce gastric cancer development, surveillance programmes for early detection of cancer in highly selected groups may increase overall survival rates in potential patients in this country.
尽管近年来全球范围内胃癌的发病率显著下降，但在伊朗北部和西北部，胃癌仍是最常见的癌症。伊朗胃癌的两个主要特征是发病率在不同地理区域存在广泛差异，以及贲门癌的比例较高。目前的研究表明，幽门螺杆菌感染率高、高盐饮食和吸烟是伊朗胃癌的主要环境因素。胃食管反流病是贲门癌高发人群的另一个致病因素。虽然应该考虑针对可改变的环境危险因素进行干预，以减少胃癌的发生，但针对特定高危人群的癌症早期检测的监测计划可能会提高该国潜在患者的总体生存率。
