Vasil'eva T G, Dobrogorskaia L N, Kraeva L N, Goncharova V P
Vopr Med Khim. 1989 Nov-Dec;35(6):48-51.
Content of alpha 2-macroglobulin (alpha 2-MG) was estimated in cerebrospinal fluid (CSF) of patients with neurosurgical impairments. Minimal content of the globulin was found in patients with brain concussion (0.011 +/- 0.001 g/L, control group), maximal concentration--in severe craniocerebral trauma with brain contraction (0.056 +/- 0.007 g/L) and moderately increased content of alpha 2-MG was detected in intracranial tumors and drug-resistant epilepsy, 0.028 +/- 0.004 g/L and 0.025 +/- 0.004 g/L, respectively. Alteration in content of alpha 2-MG during postoperational period corresponded to clinical state of patients. Estimation of alpha 2-MG in CSF might be used as a criterion of brain impairment severity as well as for monitoring the treatment course.
对患有神经外科损伤的患者的脑脊液（CSF）中α2-巨球蛋白（α2-MG）的含量进行了评估。在脑震荡患者的脑脊液中发现球蛋白含量最低（0.011±0.001g/L，对照组），最高浓度出现在伴有脑萎缩的严重颅脑创伤患者中（0.056±0.007g/L），在颅内肿瘤和耐药性癫痫患者中检测到α2-MG含量适度增加，分别为0.028±0.004g/L和0.025±0.004g/L。术后期间α2-MG含量的变化与患者的临床状态相符。脑脊液中α2-MG的评估可作为脑损伤严重程度的标准以及监测治疗过程的依据。
