Baird A E G, Carter S D, Innes J F, Ollier W, Short A
Department of Infection Biology, Institute of Infection and Global Health, School of Veterinary Science, University of Liverpool, Liverpool, L3 5RF, UK; CIGMR (Centre for Integrated Genomic Medical Research), Faculty of Medical and Human Sciences Manchester University, Manchester, M13 9PT, UK.
Anim Genet. 2014 Aug;45(4):542-9. doi: 10.1111/age.12162. Epub 2014 May 16.
Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.
颅交叉韧带破裂（CCLR）是犬只后肢跛行最常见的原因。为了研究犬类CCLR的遗传基础，我们使用犬类单核苷酸多态性（SNP）芯片，对有或没有CCLR的纽芬兰纯种犬（n = 96）进行了全基因组关联研究。我们确定了与CCLR相关的三个主要染色体区域（位于第1、3和33号染色体上）。在另一组纽芬兰犬（n = 271）中，通过Sequenom基因分型对这些区域进行了逐一验证。研究结果，特别是在SORCS2和SEMA5B基因中鉴定出的SNP，表明犬类CCLR易感性可能涉及神经通路。
