von Pfeil D J F, Sung J, Barry J, Hayashi K, Edwards M R
Dirsko J.F. von Pfeil, Dr.med.vet, DVM, Diplomate ACVS, Diplomate ECVS, Friendship Surgical Services of the, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, DC 20016, United States, Phone: +1 202 363 7300, Fax: +1 202 363 7126, E-mail:
Vet Comp Orthop Traumatol. 2015;28(6):371-8. doi: 10.3415/VCOT-15-02-0034. Epub 2015 Oct 1.
To evaluate whether doxycycline administered to dogs with unilateral cranial cruciate ligament rupture (Uni-CCLR) would decrease the risk of contralateral-CCLR (Co-CCLR). To evaluate predictors for Co-CCLR survival. To evaluate if a predisposition of Labrador Retrievers to Co-CCLR exists when compared to other breeds.
In this prospective randomized controlled clinical trial, 69 client-owned dogs with Uni-CCLR were randomly assigned to a doxycycline (group-D: 7.5 mg/kg PO BID x 6 weeks) or non-doxycycline (group-ND: negative control). Medical and imaging data, time from Uni- to Co-CCLR and to follow-up were recorded. Statistics included chi-squared test, logistic regression, Kaplan-Meier survival analysis, log rank test, survival curves, and frailty model (p <0.05).
This study included 32 dogs in group-D, and 37 dogs in group-ND. Median follow-up was 54.5 and 61 months, respectively. Contralateral CCLR occurred in 53.1% and 48.6% at medians of 20 and 11 months, respectively. Doxycycline did not significantly decrease the risk of Co-CCLR (p = 0.83). This risk was decreased by 14.2% with each year of age but increased with each increasing kilogram of body weight and each increasing degree of tibial plateau angle by 5.4% and 9.7%, respectively. Labrador Retrievers were not significantly predisposed (p = 0.37).
At the dose regimen investigated doxycycline does not decrease the risk for Co-CCLR.
评估给予单侧颅交叉韧带断裂（Uni-CCLR）犬强力霉素是否会降低对侧颅交叉韧带断裂（Co-CCLR）的风险。评估Co-CCLR存活的预测因素。评估与其他品种相比，拉布拉多寻回犬是否存在Co-CCLR的易感性。
在这项前瞻性随机对照临床试验中，69只患Uni-CCLR的客户拥有犬被随机分配至强力霉素组（D组：7.5mg/kg口服，每日两次，共6周）或非强力霉素组（ND组：阴性对照）。记录医疗和影像数据、从Uni-CCLR到Co-CCLR的时间以及随访时间。统计学方法包括卡方检验、逻辑回归、Kaplan-Meier生存分析、对数秩检验、生存曲线和脆弱模型（p<0.05）。
本研究包括D组32只犬和ND组37只犬。中位随访时间分别为54.5个月和61个月。对侧CCLR分别在20个月和11个月的中位时间发生，发生率分别为53.1%和48.6%。强力霉素并未显著降低Co-CCLR的风险（p = 0.83）。该风险随年龄每增加一岁降低14.2%，但随体重每增加一公斤和胫骨平台角每增加一度分别增加至5.4%和9.7%。拉布拉多寻回犬没有显著的易感性（p = 0.37）。
在所研究的剂量方案下，强力霉素不会降低Co-CCLR的风险。
