速激肽对人支气管黏液分泌的体外影响。
Effects of tachykinins on mucus secretion in human bronchi in vitro.
作者信息
Rogers D F, Aursudkij B, Barnes P J
机构信息
Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
出版信息
Eur J Pharmacol. 1989 Dec 19;174(2-3):283-6. doi: 10.1016/0014-2999(89)90322-1.
We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.
我们使用岩藻糖作为黏液的内源性标志物，在体外研究了哺乳动物速激肽对人支气管分泌的影响。P物质（SP，10⁻⁹ - 10⁻⁵ M）以剂量相关的方式增加分泌，且比神经激肽A或神经激肽B更有效。脑啡肽酶（内肽酶24.11）抑制剂磷酰胺素（10⁻⁵ M）增强了SP（10⁻⁷ M）的作用。SP是人类支气管分泌的有效刺激物，脑啡肽酶可能会调节其作用。
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