Yang Yu-Tsai, Shi Yi, Jay Michael, Di Pasqua Anthony J
Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Chem Res Toxicol. 2014 Jun 16;27(6):946-8. doi: 10.1021/tx5001128. Epub 2014 May 20.
Naturally occurring phenethyl isothiocyanate (PEITC) was previously shown to sensitize human non-small cell lung cancer (NSCLC) cells to the platinum anticancer drug cisplatin (CDDP). Here, CDDP and PEITC were encapsulated in approximately 130 nm liposomes composed of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and L-α-phosphatidylglycerol (EPG). The liposomal formulation enhanced the toxicity of this doublet (1:2 molar ratio of CDDP/PEITC) toward NCI-H596 NSCLC cells; the percent survival of cells was 30.2±6.2% after treatment with the nanoparticle formulation, compared to 50.9±3.5% when administered together free. Thus, such a treatment modality could prove useful in the clinic for the treatment of NSCLC.
天然存在的苯乙基异硫氰酸酯（PEITC）此前已被证明可使人类非小细胞肺癌（NSCLC）细胞对铂类抗癌药物顺铂（CDDP）敏感。在此，将CDDP和PEITC包裹在由1,2-二硬脂酰-sn-甘油-3-磷酸胆碱（DSPC）和L-α-磷脂酰甘油（EPG）组成的约130 nm脂质体中。该脂质体制剂增强了这种二元组合（CDDP/PEITC摩尔比为1:2）对NCI-H596 NSCLC细胞的毒性；用纳米颗粒制剂处理后细胞的存活率为30.2±6.2%，而游离药物联合给药时为50.9±3.5%。因此，这种治疗方式在临床上可能对NSCLC的治疗有用。
