暴露于超发光二极管阵列发出的624纳米光后白色念珠菌的失活
Inactivation of Candida albicans following exposure to 624-nanometer light from a supraluminous diode array.
作者信息
Guffey J Stephen, Payne William, James Leslie, Qian Zhuoyuan, Dodson Carly
机构信息
J. Stephen Guffey, PT, EdD, is an Associate Professor of Physical Therapy; William Payne, MS, ASCP(MT), is an Assistant Professor of Clinical Laboratory Science; Leslie James, BS, is a Doctor of Physical Therapy Student; Zhuoyuan Qian, BS, is a Doctor of Physical Therapy Student; and Carly Dodson is a Clinical Laboratory Science Student; all at Arkansas State University, Jonesboro, Arkansas. Dr Guffey has disclosed that he is a consultant for Dynatronics Corporation. The coauthors have disclosed that they have no financial relationships related to this article.
出版信息
Adv Skin Wound Care. 2014 Jun;27(6):268-71. doi: 10.1097/01.ASW.0000443268.25288.63.
OBJECTIVE
To determine the potential for visible light (405 or 624 nm) to produce an inhibitory effect on Candida albicans. In addition, the study sought to evaluate a series of doses in terms of their respective inhibiting capabilities.
BACKGROUND DATA
The authors have studied the effect of blue light on Staphylococcus aureus and found that a bactericidal outcome can be obtained with low doses of blue light.
METHODS
Candida albicans was tested because of its common appearance in human skin and mucous membrane infections. The organism was treated in vitro with 405-nm (blue) and with 624-nm (red) light emitted from a supraluminous diode array. Doses of 3, 9, 15, 30, and 60 J/cm(2) were used. Colony counts were performed and compared with untreated controls using Student t tests and 1-way analysis of variance with Tukey post hoc analysis.
RESULTS
The results revealed no inhibition produced by 405 nm on C albicans (F4,20 = 0.901; P = .482). However, 624 nm did inhibit growth of C albicans at 3, 9, and 30 J/cm(2) (F4,20 = 6.064; P = .002).
CONCLUSIONS
Appropriate doses of 624-nm light from a supraluminous diode array can inhibit the growth of C albicans in vitro. Three, 9, and 30 J/cm(2) are all effective dose levels.
目的
确定可见光（405或624纳米）对白色念珠菌产生抑制作用的可能性。此外，该研究试图评估一系列剂量各自的抑制能力。
背景数据
作者研究了蓝光对金黄色葡萄球菌的影响，发现低剂量蓝光可产生杀菌效果。
方法
对白色念珠菌进行测试，因其常见于人类皮肤和黏膜感染。该生物体在体外接受来自超发光二极管阵列发出的405纳米（蓝光）和624纳米（红光）照射。使用的剂量为3、9、15、30和60 J/cm²。进行菌落计数，并使用Student t检验以及带有Tukey事后分析的单向方差分析与未处理的对照组进行比较。
结果
结果显示405纳米对白色念珠菌没有产生抑制作用（F4,20 = 0.901；P = 0.482）。然而，624纳米在3、9和30 J/cm²时确实抑制了白色念珠菌的生长（F4,20 = 6.064；P = 0.002）。
结论
来自超发光二极管阵列的适当剂量的624纳米光可在体外抑制白色念珠菌的生长。3、9和30 J/cm²均为有效剂量水平。
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