Sleep Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Psychiatry Clin Neurosci. 2015 Feb;69(2):84-92. doi: 10.1111/pcn.12206. Epub 2014 Jul 7.
Previous studies showed enhanced attention and decreased inhibitory processes during early non-rapid eye movement sleep in primary insomnia patients, as measured by event-related potentials. The current study aims to examine information processing during sleep in non-insomniac individuals with high vulnerability (HV) to stress-related sleep disturbances.
Twenty-seven non-insomniac individuals were recruited, 14 with low vulnerability and 13 with HV. After passing a screening interview and polysomnographic recording, subjects came to the sleep laboratory for 2 nights (a baseline night and a stress-inducing night) for event-related potentials recordings.
The HV group demonstrated shorter P2 latency during the first 5 min of stage 2 sleep and higher P900 amplitudes under the stress condition during slow-wave sleep, which indicates an increased level of inhibitory processes. In addition, they had shorter N1 latencies during slow-wave sleep that could indicate an elevated level of attention processing during deep sleep.
Unlike patients with chronic insomnia, individuals with high sleep vulnerability to stress show a compensatory process that may prevent external stimulation from interfering with their sleep. This may be one of the factors preventing their acute sleep disturbances from becoming chronic problems.
先前的研究表明，原发性失眠患者在非快速眼动睡眠早期的注意力增强，抑制过程减少，这可以通过事件相关电位来衡量。本研究旨在检查易受与压力相关的睡眠障碍影响的非失眠个体在睡眠期间的信息处理情况。
共招募了 27 名非失眠个体，其中 14 名低易感性，13 名高易感性。通过筛查访谈和多导睡眠图记录后，受试者在睡眠实验室进行了 2 个晚上（基线晚上和应激诱导晚上）的事件相关电位记录。
高易感性组在第 2 阶段睡眠的前 5 分钟内表现出 P2 潜伏期缩短，在慢波睡眠期间应激条件下 P900 振幅升高，这表明抑制过程增强。此外，他们在慢波睡眠期间的 N1 潜伏期较短，这可能表明在深度睡眠期间注意力处理水平升高。
与慢性失眠患者不同，对压力易感性高的个体表现出一种代偿性过程，这可能可以防止外部刺激干扰他们的睡眠。这可能是防止其急性睡眠障碍发展为慢性问题的因素之一。
