Vargas Ivan, Friedman Naomi P, Drake Christopher L
Department of Psychology, University of Michigan, Ann Arbor, MI.
Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado, Boulder, CO.
Transl Issues Psychol Sci. 2015 Mar 1;1(1):57-66. doi: 10.1037/tps0000015.
Greater sleep difficulty following a challenging event, or a vulnerability to stress-related sleep disturbance (i.e., sleep reactivity), is characteristic of insomnia. However, insomnia is rarely observed in isolation; rather it is frequently seen in combination with other problems, such as depression. Despite the link between depression and increased sensitivity to stress, relatively little is known about the role sleep reactivity has in explaining variability in depressive symptoms. Therefore, the current study examined whether sleep reactivity was associated with depressive symptoms, and whether this relationship was mediated by insomnia. We assessed sleep reactivity, insomnia, and depressive symptoms among 2250 young adults (1244 female; = 23.1, = 2.97) from the Colorado Longitudinal Twin Study and Community Twin Study. Results indicated that greater sleep reactivity was significantly associated with elevated depressive symptoms, and that this link was partially mediated by insomnia. This is one of the first studies to demonstrate an independent association between sleep reactivity and depressive symptomatology. These findings suggest that a greater sensitivity to stress-related sleep disturbance may also be a predisposing factor to depression, and highlight the need for a better understanding of sleep reactivity, as it may represent a more global vulnerability construct.
在经历具有挑战性的事件后出现更大的睡眠困难，或易受与压力相关的睡眠障碍影响（即睡眠反应性），是失眠的特征。然而，失眠很少单独出现；相反，它经常与其他问题一起出现，比如抑郁症。尽管抑郁症与对压力的敏感性增加之间存在联系，但关于睡眠反应性在解释抑郁症状变异性方面所起的作用，人们了解得相对较少。因此，本研究探讨了睡眠反应性是否与抑郁症状相关，以及这种关系是否由失眠介导。我们评估了来自科罗拉多纵向双生子研究和社区双生子研究的2250名年轻人（1244名女性；平均年龄 = 23.1岁，标准差 = 2.97）的睡眠反应性、失眠和抑郁症状。结果表明，更高的睡眠反应性与抑郁症状的升高显著相关，并且这种联系部分由失眠介导。这是首批证明睡眠反应性与抑郁症状学之间存在独立关联的研究之一。这些发现表明，对与压力相关的睡眠障碍更敏感也可能是抑郁症的一个诱发因素，并突出了更好地理解睡眠反应性的必要性，因为它可能代表一种更全面的易感性结构。
