A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy.
作者信息
Hanna Diane M T, Fellowes Andrew, Vedururu Ravikiran, Mechinaud Francoise, Hansford Jordan R
机构信息
Children's Cancer Centre, Royal Children's Hospital, Victoria, Australia.
Molecular Pathology Laboratory, Peter MacCallum Cancer Centre, Victoria, Australia.
出版信息
Haematologica. 2014 Sep;99(9):e156-8. doi: 10.3324/haematol.2014.108142. Epub 2014 May 16.
Abstract
摘要
相似文献
1
A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy.一例伴有JAK3突变的难治性原发性纵隔B细胞淋巴瘤的独特病例及靶向治疗的作用。
Haematologica. 2014 Sep;99(9):e156-8. doi: 10.3324/haematol.2014.108142. Epub 2014 May 16.
2
Combined use of tofacitinib (pan-JAK inhibitor) and ruxolitinib (a JAK1/2 inhibitor) for refractory T-cell prolymphocytic leukemia (T-PLL) with a JAK3 mutation.托法替布（泛JAK抑制剂）与鲁索替尼（JAK1/2抑制剂）联合用于治疗伴有JAK3突变的难治性T细胞幼淋巴细胞白血病（T-PLL）。
Leuk Lymphoma. 2019 Jul;60(7):1626-1631. doi: 10.1080/10428194.2019.1594220. Epub 2019 Apr 18.
3
Hitting back at lymphoma: How do modern diagnostics identify high-risk diffuse large B-cell lymphoma subsets and alter treatment?回击淋巴瘤：现代诊断如何识别高危弥漫性大 B 细胞淋巴瘤亚群并改变治疗方法？
Cancer. 2019 Sep 15;125(18):3111-3120. doi: 10.1002/cncr.32145. Epub 2019 Jul 9.
4
The management of primary mediastinal B-cell lymphoma with sclerosis.原发性纵隔硬化性B细胞淋巴瘤的管理
Ann Oncol. 1994 Dec;5(10):943-7. doi: 10.1093/oxfordjournals.annonc.a058734.
5
A single-institution retrospective analysis of outcomes for stage I-II primary mediastinal large B-cell lymphoma treated with immunochemotherapy with or without radiotherapy.一项单机构回顾性分析，研究接受免疫化疗联合或不联合放疗的 I-II 期原发性纵隔大 B 细胞淋巴瘤的治疗结果。
Leuk Lymphoma. 2016;57(3):604-8. doi: 10.3109/10428194.2015.1067700. Epub 2015 Aug 28.
6
Tofacitinib as the potent treatment for refractory pemphigus: A possible alternative treatment for pemphigus.托法替尼治疗难治性天疱疮：天疱疮的一种可能替代治疗方法。
Dermatol Ther. 2018 Sep;31(5):e12696. doi: 10.1111/dth.12696. Epub 2018 Sep 11.
7
Primary mediastinal large B-cell lymphoma.原发性纵隔大B细胞淋巴瘤
Oncologist. 2006 May;11(5):488-95. doi: 10.1634/theoncologist.11-5-488.
8
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.PTPN6功能丧失性突变通过JAK3激酶促进弥漫性大B细胞淋巴瘤中的STAT3失调。
Oncotarget. 2015 Dec 29;6(42):44703-13. doi: 10.18632/oncotarget.6300.
9
JAK inhibitors: treatment efficacy and safety profile in patients with psoriasis.JAK 抑制剂：治疗银屑病患者的疗效和安全性特征。
J Immunol Res. 2014;2014:283617. doi: 10.1155/2014/283617. Epub 2014 May 5.
10
Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan.胸膜或心包积液在原发性纵隔大B细胞淋巴瘤中的预后意义及最佳治疗的启示：日本一项多中心回顾性研究
Haematologica. 2014 Dec;99(12):1817-25. doi: 10.3324/haematol.2014.111203. Epub 2014 Sep 12.
引用本文的文献
1
Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo.在体外和体内实验中，JAK 突变激活可导致 FLT3-ITD 阳性 AML 对 FLT3 激酶抑制剂产生耐药性。
Leukemia. 2021 Jul;35(7):2017-2029. doi: 10.1038/s41375-020-01077-1. Epub 2020 Nov 4.
2
Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models.部分 21 三体导致 JAK3 激活突变在小鼠模型中诱导的 T 细胞恶性肿瘤。
Blood Adv. 2018 Jul 10;2(13):1616-1627. doi: 10.1182/bloodadvances.2018016089.
3
JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications.靶向JAK激酶治疗血液系统恶性肿瘤：从基因改变的识别到临床应用的曲折之路
Haematologica. 2015 Oct;100(10):1240-53. doi: 10.3324/haematol.2015.132142.
4
Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.靶向测序确定了T细胞急性淋巴细胞白血病中IL7R-JAK突变与表观遗传调节因子之间的关联。
Haematologica. 2015 Oct;100(10):1301-10. doi: 10.3324/haematol.2015.130179. Epub 2015 Jul 23.
本文引用的文献
1
Tofacitinib: The First Janus Kinase (JAK) inhibitor for the treatment of rheumatoid arthritis.托法替布：首个用于治疗类风湿关节炎的 Janus 激酶（JAK）抑制剂。
Ann Pharmacother. 2013 Nov;47(11):1524-31. doi: 10.1177/1060028013512790.
2
Ofatumumab in combination with ICE or DHAP chemotherapy in relapsed or refractory intermediate grade B-cell lymphoma.奥法妥木单抗联合 ICE 或 DHAP 化疗治疗复发或难治性中等级别 B 细胞淋巴瘤。
Blood. 2013 Jul 25;122(4):499-506. doi: 10.1182/blood-2012-12-472027. Epub 2013 May 21.
3
Tofacitinib and other kinase inhibitors in the treatment of psoriasis.托法替布及其他激酶抑制剂在银屑病治疗中的应用
Actas Dermosifiliogr. 2013 May;104(4):304-10. doi: 10.1016/j.adengl.2013.03.002. Epub 2013 Apr 11.
4
Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib.针对淋巴瘤中的 JAK-STAT 通路：聚焦帕克里替尼。
Expert Opin Investig Drugs. 2013 Jun;22(6):775-85. doi: 10.1517/13543784.2013.775244. Epub 2013 Feb 26.
5
Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.JAK2 和 JAK3 抑制剂：2010-2012 年专利文献更新。
Expert Opin Ther Pat. 2013 Apr;23(4):449-501. doi: 10.1517/13543776.2013.765862. Epub 2013 Feb 1.
6
Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.自然杀伤/T 细胞淋巴瘤中鉴定出的 Janus 激酶 3 激活突变。
Cancer Discov. 2012 Jul;2(7):591-7. doi: 10.1158/2159-8290.CD-12-0028. Epub 2012 Jun 15.
7
Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing.利用超深度靶向测序检测实体瘤中的低发生率种系突变。
Genome Biol. 2011 Dec 20;12(12):R124. doi: 10.1186/gb-2011-12-12-r124.
8
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma.FERM 结构域突变在成人 T 细胞白血病/淋巴瘤中诱导 JAK3 获得性功能。
Blood. 2011 Oct 6;118(14):3911-21. doi: 10.1182/blood-2010-12-319467. Epub 2011 Aug 5.
9
The molecular pathogenesis of primary mediastinal large B-cell lymphoma.原发性纵隔大 B 细胞淋巴瘤的分子发病机制。
Blood. 2011 Sep 8;118(10):2659-69. doi: 10.1182/blood-2011-05-326538. Epub 2011 Jun 23.
10
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.整合分析揭示了结节性硬化性霍奇金淋巴瘤和原发性纵隔大 B 细胞淋巴瘤中 9p24.1 选择性扩增、PD-1 配体表达增加以及 JAK2 进一步诱导。
Blood. 2010 Oct 28;116(17):3268-77. doi: 10.1182/blood-2010-05-282780. Epub 2010 Jul 13.
Zotero 插件