Department of Women and Children Health, School of Medicine, Padua University, Azienda Ospedaliera di Padova, Padua, Italy.
Independent Statistician, Padua, Italy.
J Pediatr. 2014 Aug;165(2):261-266.e1. doi: 10.1016/j.jpeds.2014.04.010. Epub 2014 May 14.
To evaluate whether a polyethylene total body wrapping (covering both the body and head) is more effective than conventional treatment (covering up to the shoulders) in reducing perinatal thermal losses in very preterm infants.
This was a multicenter, prospective, randomized, parallel 1:1, unblinded, controlled trial of infants<29 weeks' gestation age, comprising two study groups: experimental group (total body group; both the body and head covered with a polyethylene occlusive bag, with the face uncovered) and control group (only the body, up to the shoulders, covered with a polyethylene occlusive bag). The primary outcome was axillary temperature on neonatal intensive care unit admission immediately after wrap removal.
One hundred randomly allocated infants (50 in the total body group and 50 controls) completed the study. Mean axillary temperature on neonatal intensive care unit admission was similar in the two groups (36.5±0.6°C total body vs 36.4±0.8°C controls; P=.53). The rate of moderate hypothermia (temperature<36°C) was 12% in the total body group and 20% in the control group (P=.41). Three subjects in each group (6.0%) had an axillary temperature>37.5°C on admission, and one subject in control group had an axillary temperature>38°C.
Total body wrapping is comparable with covering the body up to the shoulders in preventing postnatal thermal losses in very preterm infants.
评估聚乙烯全身包裹（覆盖身体和头部）是否比传统治疗（覆盖肩部以上）更能减少极早产儿的围产期热损失。
这是一项多中心、前瞻性、随机、平行 1:1、非盲、对照试验，纳入妊娠<29 周的婴儿，分为两组：实验组（全身组；身体和头部均用聚乙烯密闭袋覆盖，面部暴露）和对照组（仅身体、肩部以上用聚乙烯密闭袋覆盖）。主要结局为包裹去除后即刻新生儿重症监护病房入院时的腋温。
100 名随机分配的婴儿（全身组 50 名，对照组 50 名）完成了研究。两组入院时腋温相似（全身组 36.5±0.6°C vs 对照组 36.4±0.8°C；P=.53）。中度低体温（体温<36°C）的发生率全身组为 12%，对照组为 20%（P=.41）。两组各有 3 名（6.0%）受试者入院时腋温>37.5°C，对照组有 1 名受试者腋温>38°C。
全身包裹与覆盖身体至肩部在预防极早产儿出生后热损失方面效果相当。
