Sola Augusto, Golombek Sergio G, Montes Bueno María Teresa, Lemus-Varela Lourdes, Zuluaga Claudia, Domínguez Fernando, Baquero Hernando, Young Sarmiento Alejandro E, Natta Diego, Rodriguez Perez Jose M, Deulofeut Richard, Quiroga Ana, Flores Gabriel Lara, Morgues Mónica, Pérez Alfredo García-Alix, Van Overmeire Bart, van Bel Frank
Ibero American Society of Neonatology (SIBEN), Dana Point, CA, USA; New York Medical College, Valhalla, NY, USA.
Acta Paediatr. 2014 Oct;103(10):1009-18. doi: 10.1111/apa.12692. Epub 2014 Jul 28.
Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials.
SpO2 of 85-89% can increase mortality and 91-95% can cause hyperoxia and ill effects. Neither of these ranges can be recommended, and wider intermediate targets, such as 87-94% or 88-94%, may be safer.
氧气是一种对新生儿健康有害的物质，在临床实践中应避免使用。在本综述中，一个由新生儿科医生和护士组成的国际团队评估了早产儿的血氧饱和度（SpO2）目标，并评估了随机临床试验的潜在缺陷。
血氧饱和度为85 - 89%会增加死亡率，而91 - 95%会导致高氧血症及不良影响。这两个范围均不建议采用，更宽的中间目标范围，如87 - 94%或88 - 94%，可能更安全。
