Department of Gastroenterology, Dıskapı Yıldırım Beyazıt Educational and Research Hospital, 06080, Altındag, Ankara, Turkey.
Dig Dis Sci. 2014 Oct;59(10):2588-93. doi: 10.1007/s10620-014-3205-4. Epub 2014 May 18.
The values of C-reactive protein (CRP) can prove useful in determining disease progress. Because of synthesis by the liver, production of CRP in response to inflammation may be attenuated in patients with liver dysfunction. This may result in differences interpreting CRP levels in patient with portal and non-portal hypertension ascites.
The aim of the present study is to assess discriminant value of serum and ascitic fluid CRP, which is easily accessible and inexpensive laboratory marker of inflammation, concentrations for diagnosis of underlying cause of ascites.
This prospective study was conducted at Dıskapı Yıldırım Beyazıt Educational and Research Hospital Department of Gastroenterology. Patients with ascites were further divided into two subgroups based on underlying cause of ascites: Group 1, patient with ascites due to portal hypertensive etiology (high-gradient ascites); Group 2, patient with ascites due to non-portal hypertensive etiology (low-gradient ascites).
A total of 91 patients fulfilling the criteria for a diagnosis of ascites were enrolled in the study. Of these patients, 50 had proven (Group 1) ascites due to portal hypertensive etiology (high-gradient ascites) and 41 had clinical (Group 2) ascites due to non-portal hypertensive etiology (low-gradient ascites). Mean baseline serum and ascites levels of CRP were significantly higher in Group 2 compared to those in Group 1 (p = 0.021, p = <0.0001, respectively).
Increased levels of serum and ascitic fluid CRP were associated with malignant ascites.
C 反应蛋白（CRP）的值可用于确定疾病的进展。由于肝脏合成，CRP 对炎症的产生可能会在肝功能障碍的患者中减弱。这可能导致对门脉高压和非门脉高压性腹水患者的 CRP 水平的解释存在差异。
本研究旨在评估血清和腹水 CRP 这一易于获取且价格低廉的炎症实验室标志物，对于诊断腹水潜在病因的鉴别价值。
这项前瞻性研究在迪亚斯帕伊耶尔德兹姆贝伊扎蒂尔教育和研究医院胃肠病学部进行。腹水患者根据腹水的潜在病因进一步分为两组：第 1 组，由门脉高压病因引起的腹水患者（高梯度腹水）；第 2 组，由非门脉高压病因引起的腹水患者（低梯度腹水）。
共有 91 名符合腹水诊断标准的患者入组本研究。其中，50 名患者被证实（第 1 组）存在由门脉高压引起的腹水（高梯度腹水），41 名患者存在临床（第 2 组）由非门脉高压引起的腹水（低梯度腹水）。第 2 组的血清和腹水 CRP 基线水平明显高于第 1 组（p=0.021，p<0.0001）。
血清和腹水 CRP 水平升高与恶性腹水有关。
