BCR 同种型在 B 细胞发育和激活中的作用。

The role of BCR isotype in B-cell development and activation.

机构信息

Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany; Department of Molecular immunology, Faculty of Biology, University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

出版信息

Adv Immunol. 2014;123:101-39. doi: 10.1016/B978-0-12-800266-7.00003-0.

DOI:10.1016/B978-0-12-800266-7.00003-0

PMID:24840949

Abstract

The development and function of B lymphocytes critically depend on the non-germline B-cell antigen receptor (BCR). In addition to the diverse antigen-recognition regions, whose coding sequences are generated by the somatic DNA rearrangement, the variety of the constant domains of the Heavy Chain (HC) portion contributes to the multiplicity of the BCR types. The functions of particular classes of the HC, particularly in the context of the membrane BCR, are not completely understood. The expression of the various classes of the HC correlates with the distinct stages of B-cell development, types of B-cell subsets, and their effector functions. In this chapter, we summarize and discuss the accumulated knowledge on the role of the μ, δ, and γ HC isotypes of the conventional and precursor BCR in B-cell differentiation, selection, and engagement with (auto)antigens.

摘要

B 淋巴细胞的发育和功能严重依赖于非种系 B 细胞抗原受体 (BCR)。除了多样化的抗原识别区，其编码序列由体细胞 DNA 重排产生外，重链 (HC) 部分的恒定区的多样性也有助于 BCR 类型的多样性。特定类别的 HC 的功能，特别是在膜 BCR 的情况下，尚未完全了解。HC 的各种类别表达与 B 细胞发育的不同阶段、B 细胞亚群的类型及其效应功能相关。在本章中，我们总结并讨论了关于常规和前体 BCR 的 μ、δ 和 γ HC 同种型在 B 细胞分化、选择以及与 (自身)抗原结合中的作用的积累知识。