Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
Nat Prod Rep. 2014 Jul;31(7):953-72. doi: 10.1039/c4np00011k. Epub 2014 May 19.
Covering: up to the end of 2013. Myxobacteria produce a vast range of structurally diverse natural products with prominent biological activities. Here, we provide a detailed description and judge the potential of all antibiotically active myxobacterial compounds as lead structures, pointing out their particularities and, if known, their mode of action. Thus, the review provides an overview of the potential of specific compounds, suitable for future investigations and possible clinical applications.
截至 2013 年底。粘细菌可产生广泛的具有显著生物活性的结构多样的天然产物。在这里,我们详细描述并判断了所有具有抗生素活性的粘细菌化合物作为潜在的主要结构的可能性,指出了它们的特殊性,如果已知,还指出了它们的作用模式。因此,该综述概述了特定化合物的潜力,适合未来的研究和可能的临床应用。