Brown M A, Hanifin J M
Department of Medicine, Oregon Health Sciences University.
Curr Opin Immunol. 1989;2(4):531-4. doi: 10.1016/0952-7915(90)90006-3.
AD is a complex, multifactorial, cutaneous manifestation of the atopic diathesis. Observations from bone marrow transplantation cases have shown transmission of the disease from atopic donors [30] and indicate that the basic defect is carried in immune and inflammatory cells which infiltrate skin lesions. Mast cells appear to be important in the initiation of inflammatory events and eosinophils may have an important role in perpetuating the response. New evidence suggests that IL-4 may be a crucial factor controlling mast cells as well as IgE production in allergic disease. The significance of the Fc&RII/CD23 in regulating IgE synthesis and its role in Langerhans' cell/antigen interactions in atopic dermatitis represents an intriguing area in need of further study.
特应性皮炎是一种复杂的、多因素的特应性素质的皮肤表现。骨髓移植病例的观察表明，该病可从特应性供体传播[30]，这表明基本缺陷存在于浸润皮肤病变的免疫和炎症细胞中。肥大细胞似乎在炎症事件的启动中起重要作用，而嗜酸性粒细胞可能在维持反应中起重要作用。新证据表明，白细胞介素-4可能是控制肥大细胞以及过敏性疾病中IgE产生的关键因素。Fc&RII/CD23在调节IgE合成中的意义及其在特应性皮炎中朗格汉斯细胞/抗原相互作用中的作用，是一个需要进一步研究的有趣领域。
