Müller K M, Röcken M, Joel D, Bonnefoy J Y, Saurat J H, Hauser C
Department of Dermatology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
J Dermatol Sci. 1991 Mar;2(2):125-33. doi: 10.1016/0923-1811(91)90022-p.
As patients with atopic dermatitis (AD) frequently have elevated serum IgE levels, the relation of this disease to CD23/Fc epsilon RII, a low affinity Fc receptor for IgE, and its soluble forms, sCD23, was studied. We examined the expression of CD23 on peripheral blood mononuclear cells (PBMC) as well as the serum IgE and sCD23 levels in 33 patients with AD and in 9 patients with psoriasis in comparison with 10 healthy donors. In AD patients, the numbers of CD23+ unfractionated PBMC and CD23+ small adherent cells were significantly elevated (P less than 0.05, resp. P less than 0.005). In psoriatic patients however, CD23 was also significantly elevated on PBMC (P less than 0.05) and on small adherent cells (P less than 0.05). There was no significant difference in the frequencies of CD23+ cells between AD and psoriasis patients. In all donors, CD23 could be detected only on B cells, but not on monocytes/macrophages. In AD patients who were examined twice, an increase or decrease of the clinical AD score was always accompanied by an increase or decrease, resp., of cell-bound CD23. The serum sCD23 level was not significantly increased in either group of patients. Our results suggest that CD23 should be considered as a nonspecific marker for B cell activation in the context of inflammation and not as a specific marker for AD.
由于特应性皮炎（AD）患者的血清IgE水平常常升高，因此对该疾病与CD23/FcεRII（一种低亲和力IgE Fc受体）及其可溶性形式sCD23之间的关系进行了研究。我们检测了33例AD患者、9例银屑病患者以及10名健康对照者外周血单个核细胞（PBMC）上CD23的表达，以及血清IgE和sCD23水平。在AD患者中，CD23⁺未分离PBMC和CD23⁺小贴壁细胞的数量显著升高（分别为P<0.05和P<0.005）。然而，在银屑病患者中，PBMC上（P<0.05）和小贴壁细胞上（P<0.05）的CD23也显著升高。AD患者和银屑病患者之间CD23⁺细胞频率无显著差异。在所有供者中，仅在B细胞上可检测到CD23，而在单核细胞/巨噬细胞上未检测到。在接受两次检查的AD患者中，临床AD评分的增加或降低总是分别伴随着细胞结合型CD23的增加或降低。两组患者的血清sCD23水平均未显著升高。我们的结果表明，在炎症背景下，CD23应被视为B细胞活化的非特异性标志物，而非AD的特异性标志物。
