一种用于G-四链体核酸的新型比色和发红光荧光双探针的研制。
Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids.
作者信息
Yan Jin-Wu, Chen Shuo-Bin, Liu Hui-Yun, Ye Wen-Jie, Ou Tian-Miao, Tan Jia-Heng, Li Ding, Gu Lian-Quan, Huang Zhi-Shu
机构信息
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
出版信息
Chem Commun (Camb). 2014 Jul 4;50(52):6927-30. doi: 10.1039/c4cc01472c.
PMID:24841696
Abstract
A tailor-made colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids was developed by incorporating a coumarin-hemicyanine fluorophore into an isaindigotone framework. The significant and distinct changes in both the color and fluorescence of this probe enable the label-free and visual detection of G-quadruplex structures.
摘要
通过将香豆素-半菁荧光团引入靛红骨架，开发了一种用于G-四链体核酸的定制比色和发红光荧光双探针。该探针的颜色和荧光都发生了显著且明显的变化，能够对G-四链体结构进行无标记可视化检测。
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