Zhang Zifeng, Li Manhong, Wang Yusheng, Wang Jing, Liu Xiaoyan, Wang Xiaojie, Fan Jing
Department of Ophthalmology,Eye Institute of Chinese People's Liberation Army,Xijing Hospital, Fourth Military Medical University,Xi'an 710032, China.
Department of Ophthalmology, Eye Institute of Chinese People's Liberation Army,Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhonghua Yan Ke Za Zhi. 2014 Mar;50(3):184-8.
To survey popularity and clinical characteristics of retinopathy of prematurity (ROP) in Xi'an area in infants with birth weight over 2 000 g.
Retrospective case-series study. ROP screening data of 1 866 infants was collected and reviewed from Department of Ophthalmology, Xijing Hospital from January 2008 to December 2012.One thousand eight hundreds and sixty-six cases (3 732 eyes) with 1 166 males and 700 females were examined. Their gestation age was (34 ± 4) weeks (24-46 weeks), and birth weight was (2 106 ± 743) g (730-4 900 g) . All the related information about infants accepted examinations was screened, inquired and recorded carefully, such as gestation age, birth weight, continuous inhalation of oxygen and respirator applied records.Whether they had asphyxia, hypoxic-ischemic encephalopathy, acute respiratory distress syndrome, pneumonia, jaundice, anemia, congenital heart disease was also recorded. Moreover the physical situations of maternity including gestational hypertension, premature rupture of amniotic fluid, placenta abruption and placenta previa were also assessed. Percentiles (P90 and P95) of birth weight in ROP infants were calculated. Birth weight over 2 000 g in ROP patients was identified as high birth weight, whereas birth weight less than 2 000 g was confirmed as low birth weight. Clinical characteristics were compared in the two groups. T-test, Chi-square test, and Fisher's exact test were used for this study.
In all the infants examined, 243 cases were screened out as ROP patients with different stages. The positive rate was 13.0%. Among them, 96 cases needed to be treated which was 39.5%. They were severer than pre-threshold Type I. P90 and P95 of birth weight percentiles of these ROP infants were 2 060 g and 2 240 g.If birth weight less than 2 000 g was confirmed as screen guideline, 9.9% patients might be excluded. There were 24 ROP infants whose birth weight were over 2 000 g with gestation age of (33 ± 3) weeks (28-40 weeks) , and with birth weight of (2 411 ± 354) g (2 100-3 300 g) .Six of them needed to be treated, which was 6.3%. Compared with ROP infants with low birth weight, they had almost same stages and risk factors.
High birth weight ROP infants occupies some proportions in Xi'an area. They has no special characteristics or severity compared with low birth weight ones.
调查西安地区出生体重超过2000g的婴儿中早产儿视网膜病变（ROP）的患病情况及临床特征。
回顾性病例系列研究。收集并分析2008年1月至2012年12月在西京医院眼科进行ROP筛查的1866例婴儿的资料。共检查1866例（3732眼），其中男1166例，女700例。胎龄为（34±4）周（24 - 46周），出生体重为（2106±743）g（730 - 4900g）。仔细筛查、询问并记录所有接受检查婴儿的相关信息，如胎龄、出生体重、持续吸氧及使用呼吸机记录等。记录婴儿是否患有窒息、缺氧缺血性脑病、急性呼吸窘迫综合征、肺炎、黄疸、贫血、先天性心脏病等。同时评估产妇的身体状况，包括妊娠期高血压、胎膜早破、胎盘早剥及前置胎盘等。计算ROP婴儿出生体重的百分位数（P90和P95）。将ROP患者中出生体重超过2000g者定义为高出生体重，出生体重低于2000g者定义为低出生体重。比较两组的临床特征。本研究采用t检验、卡方检验和Fisher精确检验。
在所有接受检查的婴儿中，共筛查出243例不同阶段的ROP患者，阳性率为13.0%。其中96例需要治疗，占39.5%，病情比阈值前I型更严重。这些ROP婴儿出生体重百分位数的P90和P95分别为2060g和2240g。若以出生体重低于2000g作为筛查标准，9.9%的患者可能被漏诊。有24例ROP婴儿出生体重超过2000g，胎龄为（33±3）周（28 - 40周），出生体重为（2411±354）g（2100 - 3300g）。其中6例需要治疗，占6.3%。与低出生体重的ROP婴儿相比，他们的病变阶段和危险因素基本相同。
西安地区高出生体重的ROP婴儿占有一定比例，与低出生体重的ROP婴儿相比，无特殊的临床特征及严重程度差异。
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