通过辅助生殖技术受孕的儿童中，与自闭症相关的基因事件没有增加。
No increase in autism-associated genetic events in children conceived by assisted reproduction.
作者信息
Ackerman Sean, Wenegrat Julia, Rettew David, Althoff Robert, Bernier Raphael
机构信息
Department of Psychiatry, School of Medicine, University of Vermont, Burlington, Vermont.
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington.
出版信息
Fertil Steril. 2014 Aug;102(2):388-93. doi: 10.1016/j.fertnstert.2014.04.020. Epub 2014 May 17.
OBJECTIVE
To understand the rate of genetic events in patients with autism spectrum disorder (ASD) who were exposed to assisted reproduction.
DESIGN
Case control study using genetics data.
SETTING
Twelve collaborating data collection sites across North America as part of the Simons Simplex Collection.
PATIENT(S): 2,760 children with ASD, for whom 1,994 had published copy number variation data and 424 had published gene mutation status available.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Rates of autism-associated genetic events in children with ASD conceived with assisted reproduction versus those conceived naturally.
RESULT(S): No statistically significant differences in copy number variations or autism-associated gene-disrupting events were found when comparing ASD patients exposed to assisted reproduction with those not exposed to assisted reproduction.
CONCLUSION(S): This is the first large genetic association to concurrently examine the genotype of individuals with ASD in relation to their exposure to ART versus natural conception, and it adds reassuring evidence to the argument that ART does not increase the risk of ASD.
目的
了解接受辅助生殖的自闭症谱系障碍（ASD）患者的基因事件发生率。
设计
使用遗传学数据的病例对照研究。
地点
作为西蒙斯单基因队列研究的一部分，北美12个合作数据收集点。
患者
2760名患有ASD的儿童，其中1994名已发表拷贝数变异数据，424名已发表基因突变状态数据。
干预措施
无。
主要观察指标
接受辅助生殖与自然受孕的ASD儿童中自闭症相关基因事件的发生率。
结果
比较接受辅助生殖的ASD患者和未接受辅助生殖的患者时，在拷贝数变异或自闭症相关基因破坏事件方面未发现统计学上的显著差异。
结论
这是首个大规模基因关联研究，同时检查了ASD个体的基因型与他们接受辅助生殖技术（ART）或自然受孕的关系，为ART不会增加ASD风险的观点增添了令人安心的证据。
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