Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo.
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo
Jpn J Clin Oncol. 2014 Jul;44(7):641-50. doi: 10.1093/jjco/hyu061. Epub 2014 May 19.
The association between meat consumption and colorectal cancer remains inconsistent among Asians. The present study systematically evaluated and meta-analyzed epidemiologic studies on the association between consumption of total and specific meats and colorectal cancer risk among Japanese.
Original data were obtained from MEDLINE searched using PubMed or from searches of the Ichushi database, complemented with manual searches. The associations were evaluated based on the strength of evidence, the magnitude of association and biologic plausibility. A meta-analysis was performed according to total meat, red and processed meat as well as poultry and site-specific cancers.
Six cohort studies and 13 case-control studies were identified. In cohort studies, most investigations found no association between total meat consumption and colon/rectal cancer, and several studies showed a weak-to-moderate positive association of red meat and processed meat consumption with colon/rectal cancer. The majority of case-control studies showed no association between total meat consumption and colon and rectal cancer; however, several ones reported a weak-to-strong positive association of red and processed consumption with colon and rectal cancer. In meta-analysis, the summary relative risks (95% confidence interval) for the highest versus lowest categories of red meat consumption were 1.16 (1.001-1.34) and 1.21 (1.03-1.43) for colorectal and colon cancer, respectively, and those for processed meat consumption were 1.17 (1.02-1.35) and 1.23 (1.03-1.47) for colorectal and colon cancer, respectively. Poultry consumption was associated with lower risk of rectal cancer; summary relative risk (95% confidence interval) was 0.80 (0.67-0.96).
High consumption of red meat and processed meat possibly increases risk of colorectal cancer or colon cancer among the Japanese population.
肉类消费与结直肠癌之间的关系在亚洲人群中仍不一致。本研究系统评估和荟萃分析了日本人群中总肉类和特定肉类消费与结直肠癌风险之间的关系的流行病学研究。
原始数据来自使用 PubMed 搜索 MEDLINE 或从 Ichushi 数据库搜索获得，辅以手动搜索。根据证据强度、关联程度和生物学合理性评估关联。根据总肉类、红色肉类和加工肉类以及家禽和特定部位癌症进行荟萃分析。
确定了 6 项队列研究和 13 项病例对照研究。在队列研究中，大多数研究发现总肉类消费与结肠癌/直肠癌之间没有关联，并且有几项研究表明红色肉类和加工肉类消费与结肠癌/直肠癌之间存在弱到中度的正相关。大多数病例对照研究表明总肉类消费与结肠癌和直肠癌之间没有关联；然而，有几项研究报告了红色和加工肉类消费与结肠癌和直肠癌之间的弱到强的正相关。荟萃分析中，红色肉类消费最高与最低类别之间的汇总相对风险（95%置信区间）分别为结直肠癌和结肠癌的 1.16（1.001-1.34）和 1.21（1.03-1.43），加工肉类消费的汇总相对风险（95%置信区间）分别为结直肠癌和结肠癌的 1.17（1.02-1.35）和 1.23（1.03-1.47）。家禽消费与直肠癌风险降低相关；汇总相对风险（95%置信区间）为 0.80（0.67-0.96）。
日本人群中，红色肉类和加工肉类的高消费可能会增加结直肠癌或结肠癌的风险。
