应用（11）C-乙酸盐 PET 和促胰液素刺激的胰腺外分泌应激试验。
An Exocrine Pancreatic Stress Test with (11)C-Acetate PET and Secretin Stimulation.
机构信息
Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Pancreas Center, Mercy Medical Center, Baltimore, Maryland; and.
出版信息
J Nucl Med. 2014 Jul;55(7):1128-31. doi: 10.2967/jnumed.113.135681. Epub 2014 May 19.
UNLABELLED
The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function.
METHODS
In this pilot study, 5 healthy volunteers underwent two 60-min dynamic (11)C-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed.
RESULTS
The baseline k1 and k2 data for all 5 volunteers were consistent. After secretin stimulation, the k1 and k2 significantly increased (paired t test P = 0.046 and P = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (P = 0.037). Increased (11)C-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion.
CONCLUSION
(11)C-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function.
目的
本研究旨在开发一种用于评估胰腺外分泌功能的非侵入性成像检测方法。
方法
在这项初步研究中，5 名健康志愿者接受了两次 60 分钟的动态 ¹¹C-乙酸 PET 研究，一次在静脉给予生长抑素前，一次在给予生长抑素后。使用单室模型和图像衍生的输入函数对胰腺的动力学进行分析。从总和图像中，测量胰腺和肝脏的标准化摄取值，并计算胰腺与肝脏的比值。
结果
所有 5 名志愿者的基线 k1 和 k2 数据均一致。生长抑素刺激后，k1 和 k2 显著增加（配对 t 检验，P=0.046 和 P=0.023）。在总和 PET 图像中，胰腺与肝脏的比值降低（P=0.037）。生长抑素刺激后，十二指肠中观察到¹¹C-乙酸的活性增加，这与生长抑素诱导的分泌一致。
结论
生长抑素刺激¹¹C-乙酸 PET 研究具有作为评估胰腺外分泌功能的非侵入性方法的潜力。
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