伊洛林健康尼日利亚人群的正常CD4计数范围。

Normal CD4 Count Range among Healthy Nigerian Population in Ilorin.

作者信息

Afolabi J K, Fadeyi A, Desalu O O, Durotoye I A, Fawibe A E, Adeboye M A N, Olawumi H O, Babatunde A S, Ernest S K, Aderibigbe S A, Saadu R, Salami A K, Aboyeji A P

机构信息

1 Peadiatric Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria.

2 Medical Microbiology & Parasitology Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria.

出版信息

J Int Assoc Provid AIDS Care. 2017 Jul/Aug;16(4):359-365. doi: 10.1177/2325957414530472. Epub 2014 May 19.

DOI:10.1177/2325957414530472

PMID:24842948

Abstract

BACKGROUND

For the establishment and monitoring of the immune status, CD4 count is critical.

OBJECTIVES

To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value.

METHODS

An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables.

RESULTS

Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm (19%-48%) and for children was 582 to 3652 cells/mm (17%-50%). CD4 count and percentage of CD4 were significantly ( P = .001) higher in females than in males, and the CD4 count declined significantly with increasing age ( r = -.174, P ≤ .0001). The percentage of CD4 count shows less variation with age ( r = -.051, P = .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 ± 260) than that of the national reference values of 847.0 ± 307.0 cells/mm ( P = .001).

CONCLUSION

We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.

摘要

背景

对于免疫状态的建立和监测，CD4计数至关重要。

目的

确定居住在伊洛林的表面健康的尼日利亚人的CD4计数范围，并与全国值进行比较。

方法

使用自动血液分析仪测定全血细胞计数和CD4计数。通过使用其他变量得出CD4计数的百分比。

结果

在1205名参与者中，成人的参考CD4计数（CD4百分比）范围为400至1288个细胞/mm（19%-48%），儿童为582至3652个细胞/mm（17%-50%）。女性的CD4计数和CD4百分比显著高于男性（P = 0.001），且CD4计数随年龄增长显著下降（r = -0.174，P≤0.0001）。CD4计数的百分比随年龄变化较小（r = -0.051，P = 0.076）。伊洛林的成年居民的绝对平均CD4计数（808±260）显著低于全国参考值847.0±307.0个细胞/mm（P = 0.001）。