Velikiĭ N N, Parkhomets P K, Simonova N Ia, Mogilevich S E, Kuchmerovskaia T M, Chichkovskaia G V
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):83-8.
Experimentally-induced alloxan diabetes was characterized in rats by a marked increase in the blood glucose level and by a number of disturbances in the concentration of metabolites and the activity of the enzymes of carbohydrate metabolism in the liver. Stimulation of gluconeogenesis in diabetes was judged by reduction of the redox condition of free NAD- and NADP-couples, by the increase in the concentration of phosphoenolpyruvate, malic oxaloacetate and phosphoenolpyruvate carboxykinase activity of the liver. Nicotinamide in a dose of 50 mg per 100 g of body weight caused a marked reduction in the blood glucose level of diabetic rats. An increase of the [NAD+]/[NADN], [NADP+]/[NADPN] ratio, a reduction of the concentration of phosphoenolpyruvate, malate and phosphoenolpyruvate carboxylase activity pointed to the inhibition of gluconeogenesis and stimulation of glycolysis in the liver of diabetic rats given nicotinamide.
实验性诱导的大鼠四氧嘧啶糖尿病的特征是血糖水平显著升高，以及肝脏中代谢物浓度和碳水化合物代谢酶活性出现多种紊乱。糖尿病中糖异生的刺激通过游离NAD - 和NADP - 偶联的氧化还原状态的降低、磷酸烯醇丙酮酸、苹果酸草酰乙酸浓度的增加以及肝脏磷酸烯醇丙酮酸羧激酶活性来判断。每100克体重50毫克剂量的烟酰胺可使糖尿病大鼠的血糖水平显著降低。[NAD + ]/[NADH]、[NADP + ]/[NADPH]比值的增加，磷酸烯醇丙酮酸、苹果酸浓度的降低以及磷酸烯醇丙酮酸羧化酶活性表明，给予烟酰胺的糖尿病大鼠肝脏中的糖异生受到抑制，糖酵解受到刺激。
