Mogilevich S E, Velikiĭ M M, Parkhomets' P K
Ukr Biokhim Zh. 1977 Nov-Dec;49(6):39-43.
The content of NAD+, NADH, NADP+, NADPH in the liver of normal, fasting rats, those on the low-carbohydrate diet and suffering from alloxan diabetes was studied as affected by nictotinamide. Changes in the NAD+ content, sum of nicotinamide coenzymes, the [NAD+] + [NADP+]/[NADH] +/- [NADPH] and [NAD+] + [NADH] (sum of nicotinamide coenzymes) ratios are mainly due to nicotinamide administration. Changes in the content of reduced forms of both nucleotides depend equally on nicotinamide administration and the physiological state of animals. Response of the rat organism to nicotinamide administration consists in a sharp intensification of NAD+ synthesis and in a less pronounced intensification of NADH, NADP+ and NADPH synthesis.
研究了烟酰胺对正常、禁食、低碳水化合物饮食及患四氧嘧啶糖尿病大鼠肝脏中NAD+、NADH、NADP+、NADPH含量的影响。NAD+含量、烟酰胺辅酶总和、[NAD+]+[NADP+]/[NADH]+/-[NADPH]以及[NAD+]+[NADH]（烟酰胺辅酶总和）比值的变化主要归因于烟酰胺的给药。两种核苷酸还原形式含量的变化同样取决于烟酰胺的给药及动物的生理状态。大鼠机体对烟酰胺给药的反应表现为NAD+合成急剧增强，而NADH、NADP+和NADPH合成增强程度较弱。
