比较西尼地平与阿折地平对伴高血压 2 型糖尿病患者血压、心率及尿白蛋白的影响：一项初步研究。
Comparison of effects of cilnidipine and azelnidipine on blood pressure, heart rate and albuminuria in type 2 diabetics with hypertension: A pilot study.
机构信息
Department of Metabolism and Endocrinology Juntendo University Graduate School of Medicine Tokyo Japan.
Department of Metabolism and Endocrinology Juntendo University Graduate School of Medicine Tokyo Japan ; Center for Molecular Diabetology Juntendo University Graduate School of Medicine Tokyo Japan.
出版信息
J Diabetes Investig. 2013 Mar 18;4(2):202-5. doi: 10.1111/jdi.12003. Epub 2012 Oct 22.
Previous studies reported that both cilnidipine and azelnidipine have a renoprotective effect compared with amlodipine. The aim of this study was to compare the effects of cilnidipine and azelnidipine on blood pressure, heart rate and albuminuria. An open-label prospective crossover trial was carried out. We recruited 19 type 2 diabetics treated with amlodipine (5 mg/day) at least for 12 weeks. At study entry, amlodipine was changed to cilnidipine (10 mg/day) or azelnidipine (16 mg/day) and each administered for 16 weeks. Then, the drugs were switched and the treatment was continued for another 16 weeks. Despite no differences in 24-h blood pressure and heart rate between cilnidipine and azelnidipine, treatment with cilnidipine resulted in a greater reduction in urinary albumin:creatinine ratio than azelnidipine. Our results suggested that cilnidipine is more efficient in reducing albuminuria than azelnidipine independent of its blood pressure lowering effect in type 2 diabetic patients with hypertension. This trial was registered with UMIN (no. 000007201).
先前的研究报告称，与氨氯地平相比，西尼地平与阿齐利地平均具有肾脏保护作用。本研究旨在比较西尼地平和阿齐利地平对血压、心率和蛋白尿的影响。进行了一项开放标签前瞻性交叉试验。我们招募了 19 名至少接受氨氯地平（5mg/天）治疗 12 周以上的 2 型糖尿病患者。在研究开始时，将氨氯地平更换为西尼地平（10mg/天）或阿齐利地平（16mg/天），并分别治疗 16 周。然后，两种药物进行交换，继续治疗 16 周。尽管西尼地平和阿齐利地平之间 24 小时血压和心率无差异，但西尼地平治疗可使尿白蛋白/肌酐比值降低幅度大于阿齐利地平。我们的结果表明，在患有高血压的 2 型糖尿病患者中，西尼地平在降低血压方面比阿齐利地平更有效，独立于其降压作用，可更有效地降低蛋白尿。本试验已在 UMIN（编号 000007201）注册。
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