Vilibić-Cavlek Tatjana, Kucinar Jasmina, Ljubin-Sternak Suncanica, Kaić Bernard, Lazarić-Stefanović Lorena, Kolarić Branko
Cent Eur J Public Health. 2014 Mar;22(1):29-33. doi: 10.21101/cejph.a3844.
Seroprevalence data on viral hepatitis in the general population vary widely. The aim of this study was to determine the prevalence of hepatitis A (HAV), hepatitis B (HBV) and hepatitis C (HCV) viruses in the general Croatian adult population undergoing routine check-ups. The seroprevalence of anti-HAV, anti-HBc and anti-HCV was 40.5%, 7.0% and 0.9%, respectively. HBsAg was found in 0.7% and anti-HBs antibodies in 24.4% of participants. Gender was not associated with HAV, HBV or HCV seropositivity. HAV and HBV seropositivity increased progressively with age (HAV from 11.7% to 90.4%, p < 0.001; HBV from 1.7% to 15.8%, p < 0.001). Participants from rural areas showed a significantly higher HBV seroprevalence rate than those from urban areas (10.7% vs. 6.1%, p = 0.007). Results of univariate and multiple logistic regression showed that older age was a significant predictor for both HAV and HBV seropositivity while rural place of residence was a significant predictor for HBV seropositivity.
普通人群中病毒性肝炎的血清流行率数据差异很大。本研究的目的是确定在接受常规体检的克罗地亚成年普通人群中甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的流行率。抗-HAV、抗-HBc和抗-HCV的血清流行率分别为40.5%、7.0%和0.9%。在0.7%的参与者中发现了HBsAg，24.4%的参与者中有抗-HBs抗体。性别与HAV、HBV或HCV血清阳性无关。HAV和HBV血清阳性率随年龄增长而逐渐升高（HAV从11.7%升至90.4%，p<0.001；HBV从1.7%升至15.8%，p<0.001）。农村地区的参与者HBV血清流行率显著高于城市地区的参与者（10.7%对6.1%，p = 0.007）。单因素和多因素逻辑回归结果显示，年龄较大是HAV和HBV血清阳性的显著预测因素，而农村居住地是HBV血清阳性的显著预测因素。
