Conte Benjamin, Zoric Lana, Bonada Gerard, Debaene Bertrand, Ripart Jacques
Département « Anesthésie -Douleur », Centre Hospitalier Régional Universitaire de Caremeau, Nîmes, Faculté de Médecine Montpellier-Nîmes, Université Montpellier I, Montpellier, France.
Can J Anaesth. 2014 Jun;61(6):558-62. doi: 10.1007/s12630-014-0148-3. Epub 2014 Mar 28.
To report rapid recovery from grade IV rocuronium-induced anaphylaxis with a large dose of sugammadex administered early after the onset of symptoms.
A 22-yr-old female without relevant medical history developed an anaphylactic reaction within three minutes of rocuronium injection at induction of anesthesia for a routine cholecystectomy. During the first six minutes, she was unresponsive to usual treatment and her condition evolved to a grade IV anaphylaxis reaction despite a cumulated dose of epinephrine 0.7 mg. Sugammadex 14 mg·kg(-1), injected six minutes after rocuronium, resulted in total resolution of all manifestations of anaphylaxis within three minutes. The patient was discharged from hospital the next day. Allergy investigations confirmed rocuronium as the cause of anaphylaxis.
Very early administration of a large dose of sugammadex may be an effective treatment for rocuronium-induced anaphylaxis.
报告在症状出现后早期给予大剂量舒更葡糖钠，IV级罗库溴铵诱导的过敏反应得以快速恢复。
一名22岁无相关病史的女性，在因常规胆囊切除术进行麻醉诱导时注射罗库溴铵后三分钟内发生过敏反应。在最初六分钟内，她对常规治疗无反应，尽管累积使用了0.7mg肾上腺素，其病情仍发展为IV级过敏反应。在罗库溴铵注射六分钟后注射14mg·kg(-1)的舒更葡糖钠，三分钟内过敏反应的所有表现完全消退。患者次日出院。过敏调查证实罗库溴铵是过敏反应的原因。
极早期给予大剂量舒更葡糖钠可能是治疗罗库溴铵诱导的过敏反应的有效方法。
