Moulana Mohadetheh, Hosick Karen, Stanford James, Zhang Huimin, Roman Richard J, Reckelhoff Jane F
Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi.
Women's Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Physiol Rep. 2014 May 20;2(5). doi: 10.14814/phy2.12022. Print 2014 May 1.
The mechanisms responsible for the gender difference in blood pressure (BP) in humans are not clear. Over the past several years we have studied the spontaneously hypertensive rat (SHR) as a model of sex differences in BP control. In the present study, we tested the hypothesis that renal vascular and microsomal epoxyeicosatrienoic acid (EET) levels are higher in females than males, and increasing vascular EETs by blocking epoxide hydrolase with AUDA will reduce BP more in males than females. Renal vascular and microsomal EETs were higher in female SHR than males. Mean arterial pressure (MAP by telemetry) was higher in males than females during the baseline period of 6 days, and although the epoxide hydrolase inhibitor, AUDA, given for 10 days increased renal microvascular EETs in both groups, AUDA did not affect MAP in either group. These data suggest that EETs do not contribute to the sex differences in hypertension in young SHR.
人类血压（BP）性别差异的机制尚不清楚。在过去几年中，我们研究了自发性高血压大鼠（SHR）作为血压控制性别差异的模型。在本研究中，我们测试了以下假设：雌性大鼠的肾血管和微粒体环氧二十碳三烯酸（EET）水平高于雄性，并且通过用AUDA阻断环氧水解酶来增加血管EETs，雄性大鼠的血压降低幅度将大于雌性。雌性SHR的肾血管和微粒体EETs高于雄性。在6天的基线期内，雄性大鼠的平均动脉压（通过遥测法测量的MAP）高于雌性，尽管给予环氧水解酶抑制剂AUDA 10天可增加两组的肾微血管EETs，但AUDA对两组的MAP均无影响。这些数据表明，EETs对年轻SHR高血压的性别差异没有影响。
