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Epoxyeicosatrienoic acids, hypertension, and kidney injury.

作者信息

Imig John D

机构信息

From the Department of Pharmacology and Toxicology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee.

出版信息

Hypertension. 2015 Mar;65(3):476-82. doi: 10.1161/HYPERTENSIONAHA.114.03585. Epub 2015 Jan 12.

DOI:10.1161/HYPERTENSIONAHA.114.03585
PMID:25583156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4326585/
Abstract
摘要

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本文引用的文献

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Treatment-resistant hypertension and the incidence of cardiovascular disease and end-stage renal disease: results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).抗高血压和降脂治疗预防心脏病发作试验（ALLHAT）：治疗抵抗性高血压与心血管疾病和终末期肾病的发病率。
Hypertension. 2014 Nov;64(5):1012-21. doi: 10.1161/HYPERTENSIONAHA.114.03850. Epub 2014 Aug 4.
2
Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension.肾脏中产生的肿瘤坏死因子-α会导致血管紧张素II依赖性高血压。
Hypertension. 2014 Dec;64(6):1275-81. doi: 10.1161/HYPERTENSIONAHA.114.03863. Epub 2014 Sep 2.
3
Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.抑制可溶性环氧化物水解酶可预防肾间质纤维化和炎症。
Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F971-80. doi: 10.1152/ajprenal.00256.2014. Epub 2014 Aug 27.
4
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.14,15-环氧二十碳-5,8,11-三烯酸（14,15-EET）替代物：羧酸盐修饰
J Med Chem. 2014 Aug 28;57(16):6965-72. doi: 10.1021/jm500262m. Epub 2014 Aug 19.
5
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis.环氧化酶-2和可溶性环氧化物水解酶的双重抑制协同抑制原发性肿瘤生长和转移。
Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11127-32. doi: 10.1073/pnas.1410432111. Epub 2014 Jul 14.
6
Sex differences in blood pressure control in SHR: lack of a role for EETs.自发性高血压大鼠血压控制中的性别差异：环氧二十碳三烯酸无作用。
Physiol Rep. 2014 May 20;2(5). doi: 10.14814/phy2.12022. Print 2014 May 1.
7
Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an α-linolenic acid-induced inhibition of soluble epoxide hydrolase.亚麻籽的摄入通过抑制可溶环氧化物水解酶来减少α-亚麻酸诱导的循环氧化脂质，从而降低高血压患者的血压。
Hypertension. 2014 Jul;64(1):53-9. doi: 10.1161/HYPERTENSIONAHA.114.03179. Epub 2014 Apr 28.
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The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.11,12-环氧二十碳三烯酸在血管内皮细胞中的生物学作用是特异性的 R/S-对映异构体，并需要 G(s) 蛋白。
J Pharmacol Exp Ther. 2014 Jul;350(1):14-21. doi: 10.1124/jpet.114.214254. Epub 2014 Apr 24.
9
Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.环氧二十碳三烯酸类似物通过血管舒张和钠通道抑制降低血压。
Clin Sci (Lond). 2014 Oct;127(7):463-74. doi: 10.1042/CS20130479.
10
Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway.膳食中的ω-3脂肪酸主要通过细胞色素P450环氧化酶途径调节人体类二十烷酸谱。
J Lipid Res. 2014 Jun;55(6):1150-64. doi: 10.1194/jlr.M047357. Epub 2014 Mar 16.