Liumbruno Giancarlo Maria, Franchini Massimo
UOC di Immunoematologia e Medicina Trasfusionale e UOC di Patologia Clinica, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy,
J Thromb Thrombolysis. 2015 Jan;39(1):118-28. doi: 10.1007/s11239-014-1086-1.
The solvent/detergent treatment is an established virus inactivation technology that has been industrially applied for manufacturing plasma derived medicinal products for almost 30 years. Solvent/detergent plasma is a pharmaceutical product with standardised content of clotting factors, devoid of antibodies implicated in transfusion-related acute lung injury pathogenesis, and with a very high level of decontamination from transfusion-transmissible infectious agents. Many clinical studies have confirmed its safety and efficacy in the setting of congenital as well as acquired bleeding disorders. This narrative review will focus on the pharmaceutical characteristics of solvent/detergent plasma and the clinical experience with this blood product.
溶剂/去污剂处理是一种成熟的病毒灭活技术，已在工业上应用于生产血浆衍生药物产品近30年。溶剂/去污剂处理的血浆是一种含有标准化凝血因子的药品，不含有与输血相关急性肺损伤发病机制有关的抗体，并且对输血传播感染因子的去污水平非常高。许多临床研究已证实其在先天性和获得性出血性疾病中的安全性和有效性。本叙述性综述将聚焦于溶剂/去污剂处理血浆的药学特性以及该血液制品的临床经验。
