Zumkley H
Medizinische Universitäts-Poliklinik Muenster, FRG.
Biol Trace Elem Res. 1988 Jan-Apr;15:139-46. doi: 10.1007/BF02990132.
Whereas defined selenium deficiency diseases are well characterized in animals, analogous syndromes in humans are unknown or occur only rarely under conditions of extreme selenium depletion. However, selenium deficiency has since been recognized to play important secondary roles in a variety of human diseases, and several of these can be prevented or treated by means of selenium supplementation. In clinical practice, the selenium status of patients should be monitored routinely, and corrective measures should be instituted to replete the Se body stores of patients where necessary. Interactions of Se with other elements are also of potentially great clinical significance. The importance of such interactions is exemplified by the effects of cadmium on selenium metabolism in spontaneously hypertensive rats.
虽然在动物中已明确界定了硒缺乏疾病的特征，但人类中类似的综合征尚不清楚，或仅在极端硒缺乏的情况下很少发生。然而，后来人们认识到硒缺乏在多种人类疾病中起重要的次要作用，其中一些疾病可以通过补充硒来预防或治疗。在临床实践中，应常规监测患者的硒状态，必要时应采取纠正措施以补充患者体内的硒储备。硒与其他元素的相互作用也可能具有重大的临床意义。镉对自发性高血压大鼠硒代谢的影响就例证了这种相互作用的重要性。
