Wang Y X, Kiem J
Institute of Medicine, Nuclear Research Center Jülich GmbH, Federal Republic of Germany.
Biol Trace Elem Res. 1988 Jan-Apr;15:89-96. doi: 10.1007/BF02990128.
The selenium content of platelets is extremely high. About half of this selenium originates from irreversible incorporation by bone marrow precursor cells, which satisfy their need for selenium even under conditions of marked selenium deficiency. In order to study the effect of increased dietary selenium supply on the concentration of selenium, glutathione peroxidase (GSH-Px-) activity, and aggregability of platelets, normal healthy subjects were supplemented with 300 micrograms of selenium as Se-rich yeast/d for 3 mo. No significant effect of Se supplementation on platelet Se and GSH-Px were observed, whereas erythrocytes accumulated Se without reaching saturation. Although platelet aggregability was variable during the period of observation, this was traced back to factors other than selenium, including environmental temperature. This study demonstrates that the selenium concentration of platelets is subject to tight physiological control also at high dietary selenium intakes.
血小板中的硒含量极高。其中约一半的硒源自骨髓前体细胞的不可逆掺入，即使在明显缺硒的情况下，这些细胞也能满足自身对硒的需求。为了研究增加膳食硒供应对血小板硒浓度、谷胱甘肽过氧化物酶（GSH-Px-）活性和血小板聚集性的影响，正常健康受试者每天补充300微克富硒酵母形式的硒，持续3个月。未观察到补充硒对血小板硒和GSH-Px有显著影响，而红细胞则积累硒且未达到饱和状态。尽管在观察期间血小板聚集性存在变化，但这可追溯到硒以外的因素，包括环境温度。本研究表明，即使在高膳食硒摄入情况下，血小板中的硒浓度也受到严格的生理控制。
