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Effect of D-penicillamine on iron uptake by isolated rat hepatocytes.

作者信息

Rama R, Sánchez J

机构信息

Departamento de Bioquímica y Fisiología, Universidad de Barcelona, Spain.

出版信息

Biol Trace Elem Res. 1988 Dec;18:105-13. doi: 10.1007/BF02917494.

DOI:10.1007/BF02917494
PMID:2484555
Abstract

D-penicillamine (beta,beta-dimethylcysteine) promotes the incorporation of iron into isolated rat hepatocytes. The mechanism for doing this remains unknown. No differences in iron distribution between control and treated cells has been observed. Ferritin appears as the main destination of internalized iron in both cases. Therefore, increasing iron storage may appear as a side effect of the use of D-penicillamine as a therapeutic agent for several diseases.

摘要

相似文献

1
Effect of D-penicillamine on iron uptake by isolated rat hepatocytes.
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Isolation of the first crystalline D-penicillamine complex of iron and some remarks on relevant aspects of metal-chelating drugs as well as metabolism disorders.
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The interaction of transferrin with isolated hepatocytes.转铁蛋白与分离的肝细胞之间的相互作用。
Biochim Biophys Acta. 1980 Dec 1;633(2):145-53. doi: 10.1016/0304-4165(80)90400-6.
3
The role of copper in iron metabolism.铜在铁代谢中的作用。
Ann Clin Lab Sci. 1980 Jul-Aug;10(4):338-44.
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Iron mobilization from cultured rat fibroblasts and hepatocytes. Effect of various drugs.培养的大鼠成纤维细胞和肝细胞中铁的动员。各种药物的作用。
FEBS Lett. 1981 May 18;127(2):204-6. doi: 10.1016/0014-5793(81)80205-0.
5
Interaction of rat IgA with cultured rat hepatocytes: binding site, drug effects.大鼠免疫球蛋白A与培养的大鼠肝细胞的相互作用：结合位点、药物作用
Toxicology. 1980;18(3):187-94. doi: 10.1016/0300-483x(80)90063-3.
6
Transferrin protein and iron uptake by cultured hepatocytes.转铁蛋白及培养肝细胞对铁的摄取
FEBS Lett. 1982 Dec 27;150(2):365-9. doi: 10.1016/0014-5793(82)80769-2.
7
Transferrin uptake by cultured rat embryo fibroblasts. The influence of lysosomotropic agents, iron chelators and colchicine on the uptake of iron and transferrin.培养的大鼠胚胎成纤维细胞对转铁蛋白的摄取。溶酶体亲和剂、铁螯合剂和秋水仙碱对铁和转铁蛋白摄取的影响。
Eur J Biochem. 1982 Apr 1;123(2):235-40. doi: 10.1111/j.1432-1033.1982.tb19758.x.
8
Iron metabolism pathways in the rat hepatocyte.大鼠肝细胞中的铁代谢途径。
Clin Physiol Biochem. 1983;1(1):3-11.
9
Hepatic iron accumulation in copper-deficient rats.缺铜大鼠肝脏铁蓄积
Br J Nutr. 1983 Nov;50(3):653-60. doi: 10.1079/bjn19830136.
10
Influence of penicillamine and various analogs on matrix-induced bone formation in rats.青霉胺及各种类似物对大鼠基质诱导骨形成的影响。
Biochem Med. 1984 Dec;32(3):331-6. doi: 10.1016/0006-2944(84)90038-3.