青霉胺及各种类似物对大鼠基质诱导骨形成的影响。

Influence of penicillamine and various analogs on matrix-induced bone formation in rats.

作者信息

Weiss R E, Field L, Gorn A, Williams C, Dux S, Ravichandran R, Gallo A A, Eswarakrishnan V, Nimni M E

出版信息

Biochem Med. 1984 Dec;32(3):331-6. doi: 10.1016/0006-2944(84)90038-3.

Abstract

D-penicillamine and a variety of analogs have been tested for their ability to interfere with the various stages of bone development using a model for endochondral bone formation. At the highest dose tested (40 mg/rat/day), D-penicillamine inhibited mineralization, D-2-Amino-3-methyl-3-[(2-acetamidoethyl)dithio]butanoic acid (II), at a relatively low dose (10 mg/day), decreased the amount of insoluble collagen in skin, mesenchymal cell proliferation on Day 3, and inhibited bone formation on Day 14. Several other compounds tested, sodium 4-[(D-1, 1-dimethyl-2-amino-2-carboxyethyl)-dithio]butanesulfinate (IV), 2-acetamidoethyl-2-acetamidoethanethiolsulfonate (V), and sodium 4-mercaptobutanesulfinate trihydrate (VI), also inhibited osteogenesis on Day 14.

摘要

已使用软骨内骨形成模型测试了D-青霉胺及其多种类似物干扰骨发育各个阶段的能力。在测试的最高剂量（40毫克/大鼠/天）下，D-青霉胺抑制矿化；D-2-氨基-3-甲基-3-[(2-乙酰氨基乙基)二硫代]丁酸（II）在相对较低剂量（10毫克/天）下，减少了皮肤中不溶性胶原蛋白的量，在第3天减少间充质细胞增殖，并在第14天抑制骨形成。测试的其他几种化合物，4-[(D-1,1-二甲基-2-氨基-2-羧乙基)-二硫代]丁烷亚磺酸钠（IV）、2-乙酰氨基乙基-2-乙酰氨基乙硫醇磺酸盐（V）和三水合4-巯基丁烷亚磺酸钠（VI），在第14天也抑制成骨作用。