Brown Hannah E, Roffman Joshua L
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA,
CNS Drugs. 2014 Jul;28(7):611-22. doi: 10.1007/s40263-014-0172-4.
This article reviews the current literature addressing the treatment of schizophrenia with vitamin supplementation. It describes the important roles that vitamins play in normal metabolism, and reviews the evidence pertaining to vitamin deficiency and supplementation in patients with schizophrenia. There is mounting evidence suggesting that vitamin supplementation, in particular with folic acid, vitamin B12 and vitamin D, may be important in treatment within certain subgroups of patients. There is a need for larger randomized controlled trials, and further studies examining the incidence of schizophrenia in countries with poor prenatal care and malnutrition, as well as in countries that have adopted mandatory folic acid fortification of grain products, are recommended.
本文综述了目前关于用维生素补充剂治疗精神分裂症的文献。它描述了维生素在正常新陈代谢中所起的重要作用，并综述了与精神分裂症患者维生素缺乏及补充相关的证据。越来越多的证据表明，维生素补充剂，特别是叶酸、维生素B12和维生素D，在某些亚组患者的治疗中可能很重要。需要进行更大规模的随机对照试验，建议进一步研究产前护理差和营养不良国家以及已强制对谷物产品强化叶酸的国家中精神分裂症的发病率。
