Department of Pediatrics, University of Arizona, Tucson, AZ, USA.
Department of Pediatrics, University of Arizona, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA.
Gastroenterol Clin North Am. 2017 Dec;46(4):797-808. doi: 10.1016/j.gtc.2017.08.011. Epub 2017 Oct 3.
Indiscriminate use of multivitamin/mineral supplements in the general population may be misguided, but patients with chronic Inflammatory Bowel Diseases (IBD) should be monitored and compensated for nutritional deficiencies. Mechanistic links between vitamin/mineral deficiencies and IBD pathology has been found for some micronutrients and normalizing their levels is clinically beneficial. Others, like vitamin A, although instinctively desirable, produced disappointing results. Restoring normal levels of the selected micronutrients requires elevated doses to compensate for defects in absorptive or signaling mechanisms. This article describes some aspects of vitamin and mineral deficiencies in IBD, and summarizes pros and cons of supplementation.
在普通人群中滥用多种维生素/矿物质补充剂可能是不明智的，但患有慢性炎症性肠病 (IBD) 的患者应监测并补偿营养缺乏。已经发现一些微量营养素与维生素/矿物质缺乏症和 IBD 病理之间存在机制联系，使这些营养素的水平正常化具有临床益处。其他营养素，如维生素 A，虽然直觉上是可取的，但结果却令人失望。恢复选定的微量营养素的正常水平需要提高剂量以补偿吸收或信号传导机制的缺陷。本文描述了 IBD 中维生素和矿物质缺乏的一些方面，并总结了补充的优缺点。
