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骨关节炎:骨关节炎研究的重点:任重道远。

Osteoarthritis: priorities for osteoarthritis research: much to be done.

机构信息

Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Suite 200, 650 Albany Street, Boston, MA 02118, USA.

出版信息

Nat Rev Rheumatol. 2014 Aug;10(8):447-8. doi: 10.1038/nrrheum.2014.76. Epub 2014 May 20.

DOI:10.1038/nrrheum.2014.76
PMID:24846498
Abstract

With a frustrating lack of progress in the development of treatments for osteoarthritis, EULAR has released recommendations to reorient research into this disease. These recommendations include focused attention on noncartilagenous tissues, the interaction of structures within the joint, the pathogenesis of osteoarthritic pain, new treatment strategies and early disease.

摘要

由于在骨关节炎治疗方法的开发方面进展令人沮丧,EULAR 发布了重新定位该疾病研究的建议。这些建议包括将重点放在非软骨组织、关节内结构的相互作用、骨关节炎疼痛的发病机制、新的治疗策略和早期疾病上。

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Osteoarthritis: priorities for osteoarthritis research: much to be done.骨关节炎:骨关节炎研究的重点:任重道远。
Nat Rev Rheumatol. 2014 Aug;10(8):447-8. doi: 10.1038/nrrheum.2014.76. Epub 2014 May 20.
2
[Osteoarthritis and obesity].[骨关节炎与肥胖]
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An update on the pathogenesis and epidemiology of osteoarthritis.骨关节炎发病机制与流行病学的最新进展
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Obesity outcomes in disease management: clinical outcomes for osteoarthritis.疾病管理中的肥胖结局:骨关节炎的临床结局
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[Progress of research in osteoarthritis. An overview of the recent knowledge on osteoarthritis: pathogenesis, evaluation and therapies].[骨关节炎的研究进展。关于骨关节炎的最新知识概述:发病机制、评估与治疗]
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本文引用的文献

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Clinical significance of worsening versus stable preradiographic MRI lesions in a cohort study of persons at higher risk for knee osteoarthritis.在一项针对膝骨关节炎高危人群的队列研究中,影像学检查前MRI病变恶化与稳定的临床意义。
Ann Rheum Dis. 2016 Sep;75(9):1630-6. doi: 10.1136/annrheumdis-2015-208129. Epub 2015 Oct 14.
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The current and future status of biomarkers in osteoarthritis.骨关节炎生物标志物的现状与未来发展态势
J Rheumatol. 2014 May;41(5):834-6. doi: 10.3899/jrheum.140094.
3
Osteoarthritis research priorities: a report from a EULAR ad hoc expert committee.
AIM2炎性小体在膝关节骨关节炎中的作用
J Inflamm Res. 2022 Nov 28;15:6453-6461. doi: 10.2147/JIR.S392652. eCollection 2022.
4
Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial.关节内高渗葡萄糖痛点注射治疗与生理盐水治疗膝骨关节炎的疗效比较:一项三盲随机对照试验方案。
BMC Complement Altern Med. 2018 May 15;18(1):157. doi: 10.1186/s12906-018-2226-5.
5
Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice.胶原蛋白XI突变降低了小鼠对负荷诱导的软骨损伤的易感性。
J Orthop Res. 2018 Feb;36(2):711-720. doi: 10.1002/jor.23731. Epub 2017 Oct 31.
6
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.RUNX2 P1 启动子的 DNA 甲基化介导软骨细胞中 MMP13 的转录。
Sci Rep. 2017 Aug 10;7(1):7771. doi: 10.1038/s41598-017-08418-8.
7
Cross-species gene modules emerge from a systems biology approach to osteoarthritis.跨物种基因模块源自骨关节炎的系统生物学研究方法。
NPJ Syst Biol Appl. 2017 May 17;3:13. doi: 10.1038/s41540-017-0014-3. eCollection 2017.
8
The protective role of nitric oxide-dependent innate immunosuppression in the early stage of cartilage damage in rats: Role of nitric oxide in cartilage damage.一氧化氮依赖性先天性免疫抑制在大鼠软骨损伤早期的保护作用:一氧化氮在软骨损伤中的作用。
Bone Joint Res. 2017 Apr;6(4):253-258. doi: 10.1302/2046-3758.64.BJJ-2016-0161.R1.
9
Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies.骨关节炎的系统方法:确定新诊断和治疗策略的途径。
J Orthop Res. 2017 Aug;35(8):1573-1588. doi: 10.1002/jor.23563. Epub 2017 Apr 24.
10
Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes.青少年和成年排球运动员软骨基质周转生物标志物的差异及其2年内的变化
J Exp Orthop. 2017 Dec;4(1):7. doi: 10.1186/s40634-017-0081-9. Epub 2017 Feb 23.
骨关节炎研究重点:EULAR 特别专家委员会报告。
Ann Rheum Dis. 2014 Aug;73(8):1442-5. doi: 10.1136/annrheumdis-2013-204660. Epub 2014 Mar 13.
4
A new approach to prevention of knee osteoarthritis: reducing medial load in the contralateral knee.预防膝骨关节炎的新方法:降低对侧膝关节的内侧负荷。
J Rheumatol. 2013 Mar;40(3):309-15. doi: 10.3899/jrheum.120589. Epub 2013 Jan 15.
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Patient characteristics that predict progression of knee osteoarthritis: a systematic review of prognostic studies.预测膝骨关节炎进展的患者特征:系统评价预后研究。
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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.衰老与骨关节炎:软骨细胞衰老和软骨基质老化改变的作用。
Osteoarthritis Cartilage. 2009 Aug;17(8):971-9. doi: 10.1016/j.joca.2009.03.002. Epub 2009 Mar 12.