Felson David T, Hodgson Richard
Medicine, Boston University School of Medicine, Suite 200, 650 Albany Street, Boston, MA 02118, USA; University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK; Clinical Epidemiology Unit, Boston University, Boston, MA, USA; NIHR Biomedical Research Unit, University of Manchester, Manchester, UK.
Clinical Epidemiology Unit, Boston University, Boston, MA, USA; NIHR Biomedical Research Unit, University of Manchester, Manchester, UK.
Rheum Dis Clin North Am. 2014 Nov;40(4):699-710. doi: 10.1016/j.rdc.2014.07.012. Epub 2014 Sep 12.
Studies suggest that many persons with painful osteoarthritis already have extensive structural disease including malalignment, which may preclude successful stabilization or reversal of disease; this provides a strong rationale for developing strategies to prevent disease or to identify and treat it early. This article reviews a variety of approaches likely to capture those at high risk of or with early disease. However, given the absence of effective treatments, it is unclear whether structural disease could be successfully slowed or prevented in those with early symptoms or at high risk of disease.
研究表明，许多患有疼痛性骨关节炎的人已经存在广泛的结构性疾病，包括关节排列不齐，这可能会妨碍疾病的成功稳定或逆转；这为制定预防疾病或早期识别和治疗疾病的策略提供了强有力的理论依据。本文综述了多种可能适用于疾病高危人群或早期患者的方法。然而，鉴于缺乏有效的治疗方法，尚不清楚对于有早期症状或疾病高危人群，结构性疾病是否能够成功减缓或预防。
