Gaiolla Rafael Dezen, Duarte Ivison Xavier, Bacchi Carlos Eduardo, Paiva Carlos Eduardo
Hematology Service, Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil ; Institute of Oncology and Hematology - ONCOMED, Botucatu, Brazil.
Consultoria em Patologia, Botucatu, Brazil.
Case Rep Oncol. 2014 Apr 9;7(1):260-5. doi: 10.1159/000362489. eCollection 2014 Jan.
Angiosarcomas are rare aggressive neoplasms of vascular endothelial origin with a high metastatic rate and poor prognosis. Involvement of the bone marrow by the angiosarcoma is exceedingly uncommon, and there have only been a few cases reported in the literature to date. Clinical manifestations and common laboratory findings of bone marrow involvement can mimic other more common bone marrow-replacing neoplasias such as lymphomas and acute leukemia. A definitive diagnosis is difficult to make from cytologic material, probably due to an associated bone marrow fibrosis, and requires bone marrow trephine biopsy with an immunohistochemical profile. Here we had the opportunity to study a case of metastatic angiosarcoma with positive cytologic findings and an unusual presentation that challenged its primary diagnosis.
血管肉瘤是一种罕见的、具有高转移率和不良预后的血管内皮源性侵袭性肿瘤。血管肉瘤累及骨髓极为罕见，迄今为止文献中仅报道过少数病例。骨髓受累的临床表现和常见实验室检查结果可模仿其他更常见的骨髓替代肿瘤，如淋巴瘤和急性白血病。从细胞学材料很难做出明确诊断，可能是由于伴有骨髓纤维化，这需要进行骨髓环钻活检并进行免疫组化分析。在此，我们有机会研究一例转移性血管肉瘤病例，其细胞学检查结果呈阳性，且表现不寻常，对其初步诊断提出了挑战。
