Hessen Erik, Reinvang Ivar, Eliassen Carl F, Nordlund Arto, Gjerstad Leif, Fladby Tormod, Wallin Anders
Department of Neurology, Akershus University Hospital, Oslo, Norway ; Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Norway.
Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Norway.
Dement Geriatr Cogn Dis Extra. 2014 Apr 9;4(1):76-85. doi: 10.1159/000360282. eCollection 2014 Jan.
BACKGROUND/AIMS: The present study aimed to add to the knowledge of mild cognitive impairment (MCI) by studying the prognosis in a relatively young cohort of patients characterized by neuropsychological criteria.
PATIENTS (MEAN AGE: 63 years) with cognitive complaints and MCI (n = 302) were recruited from two university clinics and followed for 2 years.
Pure dysexecutive MCI occurred in 11.7% of the neuropsychologically impaired patients, while 59.3 and 29.0% were characterized as having pure amnestic MCI or multidomain MCI. During the study period, the state of 2 (10.5%) of the patients with single-domain dysexecutive MCI converted to dementia, while 28 (29.2%) of the patients with pure amnestic MCI became demented. Of the patients with both executive and amnestic deficits, 28 (59.6%) became demented.
The results suggest that dysexecutive symptoms in combination with amnestic symptoms constitute a strong risk factor for dementia in young MCI patients. A significant number of patients in all subgroups showed normal test results at follow-up, indicating that a neuropsychological diagnosis needs to be supported by imaging or biomarker data.
背景/目的：本研究旨在通过对一组以神经心理学标准为特征的相对年轻患者队列的预后进行研究，以增加对轻度认知障碍（MCI）的了解。
从两家大学诊所招募了有认知主诉且患有MCI的患者（平均年龄：63岁，n = 302），并随访2年。
在神经心理学受损的患者中，单纯执行功能障碍型MCI占11.7%，而59.3%和29.0%的患者分别表现为单纯遗忘型MCI或多领域MCI。在研究期间，单领域执行功能障碍型MCI患者中有2例（10.5%）转变为痴呆，而单纯遗忘型MCI患者中有28例（29.2%）发展为痴呆。在同时存在执行功能和遗忘缺陷的患者中，有28例（59.6%）发展为痴呆。
结果表明，执行功能障碍症状与遗忘症状相结合是年轻MCI患者发生痴呆的一个强风险因素。所有亚组中相当数量的患者在随访时测试结果正常表明，神经心理学诊断需要影像学或生物标志物数据的支持。
