Obes Res Clin Pract. 2014 May-Jun;8(3):e201-98. doi: 10.1016/j.orcp.2013.03.001.
Abdominal obesity alters the composition of plasma and tissue long chain fatty acids and thus affects a number of important physiological functions relating to the development of cardiometabolic diseases. The fatty acid composition is modulated by desaturases; stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Therefore, we examined the relationship between the desaturase activities and abdominal adiposity.
One hundred eighty-one children (98 males, 83 females), including 42 children with abdominal obesity having waist to height ratio (WHtR) >0.5, were recruited. Fatty acid composition in plasma phospholipids was analyzed by gas chromatography after overnight fast, and SCD activity was estimated by 18:1/18:0 ratio.
In children without abdominal obesity, WHtR correlated positively with D6D activity (r = 0.252, p = 0.0027) and negatively with SCD activity (r = −0.289, p = 0.0006), but not with D5D activity (r = −0.159, p = 0.0607). While in children with abdominal obesity, WHtR had a positive association with SCD activity (r = 0.332, p = 0.0315), but not with D6D (r = 0.267, p = 0.0847) or D5D activity (r = 0.008, p = 0.9600).
The relationship between the desaturase activities and abdominal adiposity altered in children with abdominal obesity. Especially, SCD activity demonstrated a U-shaped association with WHtR.
腹部肥胖会改变血浆和组织中长链脂肪酸的组成，从而影响与代谢综合征相关的许多重要生理功能。脂肪酸的组成受去饱和酶调节；硬脂酰辅酶 A 去饱和酶（SCD）、δ-6 去饱和酶（D6D）和 δ-5 去饱和酶（D5D）。因此，我们研究了去饱和酶活性与腹部肥胖之间的关系。
共招募了 181 名儿童（98 名男性，83 名女性），包括 42 名腹部肥胖儿童（腰高比（WHtR）>0.5）。空腹过夜后通过气相色谱法分析血浆磷脂中的脂肪酸组成，通过 18:1/18:0 比值估计 SCD 活性。
在无腹部肥胖的儿童中，WHtR 与 D6D 活性呈正相关（r=0.252，p=0.0027），与 SCD 活性呈负相关（r=-0.289，p=0.0006），但与 D5D 活性无关（r=-0.159，p=0.0607）。而在腹部肥胖的儿童中，WHtR 与 SCD 活性呈正相关（r=0.332，p=0.0315），与 D6D 活性无关（r=0.267，p=0.0847）或 D5D 活性无关（r=0.008，p=0.9600）。
腹部肥胖儿童的去饱和酶活性与腹部肥胖的关系发生了改变。特别是 SCD 活性与 WHtR 呈 U 形关联。
