Department of Bromatology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Nutrients. 2021 May 6;13(5):1563. doi: 10.3390/nu13051563.
The purpose of this work was to evaluate the effect of the nanosized or microsized zinc (Zn) particles on fatty acid profile, enzyme activity and the level of cholesterol, squalene and oxysterols in rats with breast cancer. Rats (female, = 24) were divided into the following groups: control, and two test groups, whose diets were enriched with either Zn microparticles (342 nm) or Zn nanoparticles (99 nm). All rats were treated twice with the carcinogenic agent; 7,12-dimethylbenz[a]anthracene. In rats whose diet was enriched with zinc (especially in the form of nanoparticles), the number and sizes of tumors were lower. Diet supplementation also significantly reduced the cholesterol ( = 0.027) and COPs (cholesterol oxidation products) levels ( = 0.011) in rats serum. Enriching the diet with Zn microparticles decreased the Δ6-desaturase activity ( < 0.001). Zn influences fatty acids' profile in rats' serum as well as inhibiting desaturating enzymes. A reduced amount of pro-inflammatory arachidonic acid derivatives may be the expected effect.
这项工作的目的是评估纳米或微米级锌 (Zn) 颗粒对乳腺癌大鼠脂肪酸谱、酶活性以及胆固醇、角鲨烯和氧化固醇水平的影响。将大鼠（雌性， = 24）分为以下几组：对照组和两个实验组，实验组的饮食中分别添加了微米级 Zn 颗粒（342nm）或纳米级 Zn 颗粒（99nm）。所有大鼠均两次接受致癌剂 7,12-二甲基苯并[a]蒽处理。饮食中添加锌（尤其是以纳米颗粒形式添加）的大鼠肿瘤数量和大小较低。饮食补充还显著降低了大鼠血清中的胆固醇（ = 0.027）和 COPs（胆固醇氧化产物）水平（ = 0.011）。添加 Zn 微米颗粒降低了 Δ6-去饱和酶的活性（ < 0.001）。Zn 影响大鼠血清中脂肪酸的谱，同时抑制去饱和酶。减少促炎花生四烯酸衍生物可能是预期的效果。
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