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一项针对疼痛性骨转移姑息性放疗中单次治疗与传统分割放疗的随机试验。

A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of painful bone metastases.

作者信息

Cole D J

机构信息

Department of Radiotherapy and Oncology, Churchill Hospital, Headington, Oxford, U.K.

出版信息

Clin Oncol (R Coll Radiol). 1989 Nov;1(2):59-62. doi: 10.1016/s0936-6555(89)80035-4.

DOI:10.1016/s0936-6555(89)80035-4
PMID:2484789
Abstract

In a randomized prospective trial of radiotherapy in 29 patients. Comparing 24 Gy in six fractions is two to three weeks with a single treatment of 8 Gy in the palliative treatment of bone metastasis no differences could be detected in daily subjective pain scores for one month or monthly objective scores for six months. Of the single treatment group 25% required retreatment. Daily subjective record of nausea/vomiting, diarrhoea, skin reaction and lethargy for one month showed no difference between the two groups. Palliative radiotherapy for metastatic bone pain using a single treatment is recommended.

摘要

在一项针对29例患者的放射治疗随机前瞻性试验中。在骨转移瘤姑息治疗中，比较六周内分六次给予24 Gy与单次给予8 Gy，在为期一个月的每日主观疼痛评分或为期六个月的每月客观评分中均未发现差异。单次治疗组中有25%的患者需要再次治疗。对恶心/呕吐、腹泻、皮肤反应和乏力进行为期一个月的每日主观记录，结果显示两组之间没有差异。推荐采用单次治疗对转移性骨痛进行姑息性放疗。

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