Bildircin D, Kokcu A, Celik H, Sagir D, Kefeli M
Department of Obstetrics and Gynecology School of Medicine, University of Ondokuz Mayis Samsun, Turkey -
Minerva Ginecol. 2014 Apr;66(2):201-8.
Aim of the study was the comparison of the connective tissue components in the uterine ligaments between the women with and without pelvic organ prolapse.
This study included 15 postmenopausal women without pelvic organ prolapse who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for benign pathologies (control group) and 15 postmenopausal women who underwent vaginal hysterectomy because of pelvic organ prolapse (POP group). During the operation, samples for histological examination were taken from the cardinal and sacrouterine ligaments. The contents of collagen type I, collagen type III and elastin, and number and mitotic activity of fibroblasts in uterine ligaments were histopatholocially determined.
The collagen type I content for the POP group was significantly higher than that of the control group. Collagen type III content, elastin content, and number and mitotic activity of fibroblasts were not significantly different between the control and POP groups.
Collagen type I was found to be increased in the uterine ligaments of the POP group. The other connective tissue components did not differ between the two groups.
本研究的目的是比较有和没有盆腔器官脱垂的女性子宫韧带中的结缔组织成分。
本研究纳入了15名因良性病变接受全腹子宫切除术和双侧输卵管卵巢切除术的无盆腔器官脱垂的绝经后女性（对照组）以及15名因盆腔器官脱垂接受阴道子宫切除术的绝经后女性（盆腔器官脱垂组）。手术过程中，从主韧带和骶子宫韧带获取组织学检查样本。组织病理学测定子宫韧带中I型胶原、III型胶原和弹性蛋白的含量以及成纤维细胞的数量和有丝分裂活性。
盆腔器官脱垂组的I型胶原含量显著高于对照组。对照组和盆腔器官脱垂组之间的III型胶原含量、弹性蛋白含量以及成纤维细胞的数量和有丝分裂活性没有显著差异。
发现盆腔器官脱垂组子宫韧带中的I型胶原增加。两组之间的其他结缔组织成分没有差异。
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