Cembrzyńska-Nowak M
Department of Immunology of Infectious Diseases, Institute of Immunology and Experimental Therapy, Wrocław.
Arch Immunol Ther Exp (Warsz). 1989;37(5-6):503-8.
Interferon production by NDV-stimulated mouse cells was tested at various temperatures. The peritoneal non-adherent lymphocytes, adherent macrophages, mouse embryonic fibroblasts and L929 cells were used. Only lymphocytes produced two types of interferons depending on the temperature of incubation. Multifold stimulations of lymphocytes with NDV with parallel alterations of the temperature of incubation revealed that as early as after the first stimulation, they achieved the state of tolerance and stopped producing interferon even after repeated inductions or temperature alterations. It was also noted that the temperature of cell incubation determines the production of two types of interferon as soon as interferon appeared in the culture fluid.
在不同温度下测试了新城疫病毒（NDV）刺激的小鼠细胞产生干扰素的情况。使用了腹膜非贴壁淋巴细胞、贴壁巨噬细胞、小鼠胚胎成纤维细胞和L929细胞。只有淋巴细胞根据培养温度产生两种类型的干扰素。用新城疫病毒对淋巴细胞进行多次刺激并同时改变培养温度，结果显示，早在第一次刺激后，它们就达到了耐受状态，即使在反复诱导或温度改变后也停止产生干扰素。还注意到，一旦培养液中出现干扰素，细胞培养温度就决定了两种类型干扰素的产生。
