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第八节 小儿活体肝移植中门静脉并发症的处理

Section 8. Management of portal venous complications in pediatric living donor liver transplantation.

机构信息

1 Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Taiwan. 2 Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan. 3 Division of Hepatogastroenterology, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan. 4 Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Taiwan. 5 Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Taiwan. 6 Address correspondence to: Chao-Long Chen, M.D., Liver Transplantation Program and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Tai-Pei Road, Niao-Sung, Kaohsiung 83305, Taiwan.

出版信息

Transplantation. 2014 Apr 27;97 Suppl 8:S32-4. doi: 10.1097/01.tp.0000446272.05687.ce.

Abstract

Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good recipient survival. Small preoperation PV size (<4 mm) and slow portal flow (<10 cm/s) combined with lower hepatic artery resistance index (<0.65) are strong warning signs that may predict the development of post LDLT PV complications. Portal vein angioplasty/stenting is conventionally performed through the percutaneous transhepatic approach; however, this can also be performed through transjugular, trans-splenic, and intraoperative approaches. Depending on the situation, using optimal method is the key point to minimize complication (5%) and gain high success rate (80%). PV occlusion of greater than 1 year with cavernous transformation seems to be a factor causing technical failure. Good patency rate (100%) with self-expandable metallic stents was noted in long-term follow-up. In conclusion, PV stent placement is an effective, long-term treatment modality to manage PV complications after pediatric LDLT. Early diagnosis and treatment are essential to maximize the use of stent placement and achieve good success rates.

摘要

门静脉(PV)并发症是活体肝移植(LDLT)后儿科肝移植的主要关注点。与成人受者相比,PV 并发症在儿科患者(0%-33%)中更为常见。早期诊断和治疗 PV 并发症可以确保移植物的最佳功能和良好的受者存活率。术前门静脉较小(<4mm)、门静脉血流较慢(<10cm/s)和肝固有动脉阻力指数较低(<0.65)是可能预测 LDLT 后 PV 并发症发展的强烈警告信号。经皮经肝途径是门静脉血管成形术/支架置入术的常规方法;然而,也可以通过经颈静脉、经脾和术中途径进行。根据具体情况,选择最佳方法是将并发症(5%)发生率和高成功率(80%)降至最低的关键。>1 年的伴有海绵样变的 PV 闭塞似乎是导致技术失败的一个因素。在长期随访中,自膨式金属支架具有良好的通畅率(100%)。总之,PV 支架置入是治疗小儿 LDLT 后 PV 并发症的一种有效、长期的治疗方法。早期诊断和治疗对于最大限度地利用支架置入和获得良好的成功率至关重要。

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