Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Biomedical Research Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2014 May;29(5):676-9. doi: 10.3346/jkms.2014.29.5.676. Epub 2014 Apr 25.
The aim of this study was to review the literature of latent papillary thyroid carcinomas (PTCs) discovered at autopsy and describe the available pathologic and demographic differences from a group of papillary thyroid microcarcinomas (PTMCs) the reported in a previous publication. We searched the PubMed for published articles describing latent thyroid carcinomas detected at autopsy. Meta-analysis was performed to identify differences between the clinicopathologic features of PTMCs analyzed previously in our institution (Group I) and those of latent PTCs described in autopsy studies (Group II). We identified 1,355 patients with PTMC (Group I) and 989 with latent PTCs (Group II). Mean patient age was 47.3 yr in Group I and 64.5 yr in Group II. The male:female ratio was 1:10.9 in Group I and 1:1 in Group II. Most PTMCs (67.6%) were larger than 0.5 cm in size, whereas most latent PTCs were <1-3 mm in diameter. The rates of multifocality were 24.7% in Group I and 30.5% in Group II, and the rates of cervical lymph node metastasis were 33.4% in Group I and 10.0% in Group II. Currently available data indicated that clinically evident PTMCs differ from latent PTCs detected at autopsy. Therefore, these two entities should be regarded as different.
本研究旨在回顾尸检中发现的隐匿性甲状腺乳头状癌（PTC）的文献，并描述与先前发表的一组甲状腺微小乳头状癌（PTMC）相比，尸检中发现的隐匿性 PTC 的可用病理和人口统计学差异。我们在 PubMed 上搜索描述尸检中发现的隐匿性甲状腺癌的已发表文章。进行荟萃分析以确定之前在我们机构分析的 PTMC（I 组）的临床病理特征与尸检研究中描述的隐匿性 PTC（II 组）之间的差异。我们确定了 1355 例 PTMC（I 组）和 989 例隐匿性 PTC（II 组）患者。I 组患者的平均年龄为 47.3 岁，II 组为 64.5 岁。I 组男女比例为 1:10.9，II 组为 1:1。大多数 PTMC（67.6%）大于 0.5cm，而大多数隐匿性 PTC 直径小于 1-3mm。I 组的多灶性发生率为 24.7%，II 组为 30.5%，I 组的颈部淋巴结转移率为 33.4%，II 组为 10.0%。目前可用的数据表明，临床上明显的 PTMC 与尸检中发现的隐匿性 PTC 不同。因此，这两种实体应被视为不同的疾病。
