Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Department of Hospital Pathology, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Cancer Res Treat. 2014 Apr;46(2):204-7. doi: 10.4143/crt.2014.46.2.204. Epub 2014 Apr 22.
Development of tumor lysis syndrome (TLS) may occur after chemotherapy or spontaneously in bulky or rapidly growing tumors. This syndrome is frequent but preventable in patients with hematologic malignancies. TLS following therapy has been reported infrequently in various types of solid tumors. TLS associated with oxaliplatin containing chemotherapy in a solid tumor has never been reported. A 59-year-old man received 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy for metastatic colon cancer. Development of TLS occurred three days after administration of chemotherapy. Two days later, his abnormal laboratory findings were recovered with appropriate management. To the best of our knowledge, the current case is the first report on development of acute TLS following oxaliplatin containing chemotherapy in a patient with colon cancer. We also review the literature on tumor lysis syndrome in patients with colorectal cancer.
肿瘤溶解综合征 (TLS) 可能在化疗后或在大体积或快速生长的肿瘤中自发发生。这种综合征在血液恶性肿瘤患者中很常见，但可以预防。在各种类型的实体瘤中，TLS 继发于治疗后较为罕见。在实体瘤中接受含奥沙利铂的化疗后出现 TLS 的情况从未有过报道。一名 59 岁男性因转移性结肠癌接受氟尿嘧啶、亚叶酸钙和奥沙利铂（FOLFOX）化疗。在化疗后三天出现 TLS。两天后，他的异常实验室检查结果经适当治疗得到恢复。据我们所知，目前的病例是首例奥沙利铂治疗结肠癌患者发生急性 TLS 的报告。我们还对结直肠癌患者肿瘤溶解综合征的文献进行了回顾。
